MCI & Depression Research Study
Researchers from the Medical University of South Carolina are conducting a study on brain stimulation to improve memory, thinking, and mood in individuals with Mild Cognitive Impairment (MCI) and depression.
Fast Facts
Documented Diagnosis of mild cognitive impairment (MCI).
Medical records confirming MCI diagnosis are required.
60-85 Years Old
Compensation Provided
Conducted in South Carolina
Study Background
Researchers at the Medical University of South Carolina (MUSC) are conducting studies in brain stimulation to understand how it can improve memory, thinking, and mood in individuals with Mild Cognitive Impairment (MCI) and depression.
The PUSH Against Dementia study explores an innovative approach to cognitive health, using non-invasive transcranial magnetic stimulation (TMS) to address the challenges associated with MCI and depression. The research aims to determine the most effective dose of TMS to enhance brain function, potentially unlocking new therapeutic pathways for those living with these conditions.
Participants in the study will undergo cutting-edge diagnostic and treatment protocols, including memory and thinking skills tests, brain imaging, and TMS treatment sessions. With a commitment to advancing knowledge and improving lives, this study seeks to provide hope and solutions for individuals impacted by cognitive decline and mood disorders.
Study Background
Researchers at the Medical University of South Carolina (MUSC) are conducting studies in brain stimulation to understand how it can improve memory, thinking, and mood in individuals with Mild Cognitive Impairment (MCI) and depression.
The PUSH Against Dementia study explores an innovative approach to cognitive health, using non-invasive transcranial magnetic stimulation (TMS) to address the challenges associated with MCI and depression. The research aims to determine the most effective dose of TMS to enhance brain function, potentially unlocking new therapeutic pathways for those living with these conditions.
Participants in the study will undergo cutting-edge diagnostic and treatment protocols, including memory and thinking skills tests, brain imaging, and TMS treatment sessions. With a commitment to advancing knowledge and improving lives, this study seeks to provide hope and solutions for individuals impacted by cognitive decline and mood disorders.
Additional Information
This study aims to explore whether non-invasive brain stimulation can improve memory, thinking, and mood in individuals with Mild Cognitive Impairment (MCI) and depression. By identifying the optimal dose of stimulation, researchers hope to develop more effective treatments for these conditions, improving quality of life for those affected.
You or your loved one may qualify for this study if:
Inclusion Criteria:
- Ages 60-85
- Diagnosed with mild cognitive impairment (MCI)
- Actively experiencing depressive thoughts
- Have a study partner that is willing to participate as an informant
- No diagnosis of dementia or other major neurocognitive disorder
- No significant or unstable conditions that may impact cognition (e.g., heart failure, HIV, brain injury)
- Have not been treated with lecanemab (Lequembi), aducanumab (Aduhelm), or donanemab for MCI
- Able to undergo MRI scan
- No current diagnosis of substance use disorders
- No current diagnosis of schizophrenia or bipolar disorder
If you choose to participate in the PUSH Against Dementia study, here’s what you can expect:
Initial Screening:
- A pre-screening phone call to determine your eligibility.
- If you qualify, you will attend an eligibility screening at the study site, which may include reviewing your medical records, a blood draw, questionnaires, memory and thinking tests, and a brain MRI.
TMS Treatment Sessions:
- If eligible, you’ll be assigned a dose of transcranial magnetic stimulation (TMS) therapy.
- Over six treatment days (scheduled within a 14-day period), you’ll complete 10 TMS sessions each day. Each session lasts about 3 minutes, with 10–15-minute breaks in between.
Follow-Up Assessments:
- One week after treatment ends, you’ll repeat questionnaires, cognitive tests, and another brain MRI.
- At approximately 2 and 6 months post-treatment, you’ll be asked to complete follow-up questionnaires and memory tests to track progress.
You can earn up to $645 for completing study activities. Travel reimbursement may also be provided.
There is no cost for you to participate in our research study.