Depression Probiotic Research Study
Researchers at the University of California, San Francisco (UCSF) are conducting a study with adolescents and young adults to better understand depression and how probiotics may affect brain health and mood.
Fast Facts
Ages 15-24
Diagnosed with depression
Compensation
Provided Up To $200
Conducted in
San Fransisco, CA
Study Background
UCSF researchers are studying depression in adolescents and young adults.
Depression in adolescents and young adults has been linked to changes in brain function and the gut microbiome, which may influence mood, emotions, and overall well-being. This study aims to better understand how probiotic intake may affect brain activity and gut health in youth diagnosed with depression who are already receiving standard treatment. By studying these relationships early in life, researchers hope to identify new, supportive approaches that could complement existing depression treatments and promote healthier developmental outcomes.
The results of this study may help advance future treatment options for depression and improve quality of life for adolescents and young adults.
Study Background
UCSF researchers are studying depression in adolescents and young adults.
Depression in adolescents and young adults has been linked to changes in brain function and the gut microbiome, which may influence mood, emotions, and overall well-being. This study aims to better understand how probiotic intake may affect brain activity and gut health in youth diagnosed with depression who are already receiving standard treatment. By studying these relationships early in life, researchers hope to identify new, supportive approaches that could complement existing depression treatments and promote healthier developmental outcomes.
The results of this study may help advance future treatment options for depression and improve quality of life for adolescents and young adults.
Additional Information
In this research study, we are working to better understand depression in adolescents and young adults by examining how probiotic intake may influence brain function and the gut microbiome. The study focuses on how changes in gut bacteria may be related to brain activity, mood, and emotional processing in youth with depression. By measuring brain changes through MRI scans, along with biological samples and self-reported experiences, we aim to better understand the connection between gut health and depression. This research may help identify new supportive approaches that could complement existing treatments for depression in young people.
You may be eligible to participate in this study if you meet the following criteria.
Inclusion Criteria:
- Ages 15–24
- Diagnosed with depression
- Currently taking an SSRI medication for depression for at least 8 weeks
- Under the care of a primary care provider or mental health clinician
- Fluent in English
- Have access to a smartphone, tablet, or computer for virtual visits
Exclusion Criteria:
- Current diagnosis of another DSM-5 mental health disorder (except anxiety or medically managed ADHD)
- Use of probiotics, antibiotics, fermented foods, or certain supplements within the past month
- Contraindications for MRI (such as metal implants or braces)
- Current active suicidal ideation requiring hospitalization
- Pregnancy or plans to become pregnant during the study
The study lasts approximately 8 weeks. Once enrolled, participation includes both in-person and remote activities.
In person: Participants will visit the UCSF Mission Bay campus twice—once at the beginning of the study and once at the end. During these visits, participants will complete MRI scans and study assessments.
From home: Participants will take either a probiotic or placebo twice daily for 8 weeks. They will also self-collect stool and saliva samples and complete online questionnaires about their mood and experiences throughout the study.
As a participant, you may receive up to $200.
There is no cost for you to participate in our research study.