This study is being conducted to better understand how anxiety and attention-related conditions, such as ADHD, affect brain function in children. Researchers hope this work will help improve future treatments, diagnostic tools, and quality of life for children experiencing anxiety and attention difficulties.

You may be eligible for this research study if your child meets the following criteria.

Inclusion Criteria:

• Child is 8–12 years old
• Child experiences anxiety symptoms
• Parent/guardian and child are both able to participate in study visits and questionnaires
  
  

Exclusion Criteria:

• Diagnosis of autism or another neurological disorder/cognitive delay
• Currently taking SSRIs or medications for anxiety or depression
• Braces or other fixed dental devices
• Amblyopia (“lazy eye”)
• Current active depressive episode

Overall Duration

This study includes two in-person visits at Washington University School of Medicine in St. Louis, Missouri. Study visits are usually scheduled Monday through Friday. The full study participation is typically completed within a short period of time based on family scheduling availability.

In-Lab Activities

Participants and their parent/guardian will attend two in-person study visits.

Visit 1: EEG Visit (up to 4 hours)

During this visit:

• The child will wear a comfortable EEG cap that measures brain activity.
• The child will play a computer-based attention game while wearing the EEG equipment.
• The parent/guardian will complete a diagnostic interview with study staff.
• Both the child and parent/guardian will complete questionnaires and surveys about emotions, behavior, and attention.
  
  

Visit 2: MRI Visit (up to 2 hours)

During this visit:

• The child will complete an MRI brain scan.
• The child may watch a movie during part of the MRI scan.
• The child will also complete the same computer-based game from the EEG visit while in the MRI scanner.

The study does not involve blood draws, medication, or treatment.

Researchers will collect information from interviews, questionnaires, EEG recordings, and MRI brain images. All study information will be kept private and securely stored.

Participants may receive up to $200 for completing study activities. In addition to compensation, families will receive a research diagnostic summary letter that may provide information about possible emotional or behavioral concerns identified during the study evaluation.

Children who complete the MRI visit will also receive a picture of their brain. Snacks will be provided during study visits.

Parking is provided for all study appointments, and transportation assistance may be available for families who need help getting to and from the study site.

There is no cost for you to participate in our research study.