Researchers are studying schizophrenia to learn more about episodes of worsening symptoms that may require hospitalization. This study will evaluate an investigational medication to determine whether it may help adults experiencing a recent worsening of schizophrenia symptoms.

You may be eligible for this study if you meet the following criteria:

• Ages 18-65
• Have schizophrenia and have experienced a recent worsening or return of symptoms
• Have someone who knows your health history and can provide information to the study team
• Have not been hospitalized for psychiatric reasons for more than 30 total days within the 90 days before screening

Overall Duration

The length of participation will be discussed with eligible individuals by the study team.

In-Person Activities

This study requires in-person participation. Individuals who qualify for the study will receive study-related evaluations, monitoring, and care throughout the trial.

Participants will:

• Complete screening procedures to determine eligibility
• Meet with study staff for evaluations related to their schizophrenia symptoms
• Receive the study medication or placebo and ongoing monitoring during the study
• Be asked to have a reliable informant (such as a family member, friend, caregiver, case worker, or residential treatment staff member) who can provide information about their condition during the study

Additional study procedures and visit details will be explained by the research team.

Participants may receive up to $5,865 for taking part in this research study. The study team will provide additional details about compensation.

There is no cost for you to participate in our research study.