Epstein-Barr virus (EBV) infects more than 90% of people worldwide and is the leading cause of infectious mononucleosis (mono). Researchers are studying investigational EBV vaccines to learn more about their safety and how the body responds to them, with the goal of helping prevent EBV infection and related diseases in the future.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 18-29
• Able to attend study visits in Bethesda, MD
• In general good health (no major medical conditions such as cancer, autoimmune diseases, etc.)
• Not currently pregnant, planning to become pregnant, or currently breastfeeding
• Not currently participating in another clinical trial that involves an investigational drug, vaccine, or treatment
• Willing to allow storage of blood and saliva for future research
• Willing to use birth control for the study’s duration if sexually active

If you qualify and choose to participate, you will:

• Complete screening activities, including a medical history review, physical exam, and blood and saliva samples
• Receive 3 doses of an investigational EBV vaccine by injection in the shoulder muscle over approximately 4 months
• Attend 6 required in-person study visits and 7 telehealth or telephone follow-up visits
• Record any symptoms or side effects using a paper or electronic diary after each vaccine dose
• Provide blood samples at select visits so researchers can evaluate your immune response to the vaccine
• Remain in the study for approximately 17 months, with the option to participate in an additional year of follow-up
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Participants may receive compensation for study-related visits, with total compensation of up to $1,720 for required study visits. Additional compensation may be available for optional visits and extended follow-up participation. All study-related care provided through the NIH is free of charge, and clinical laboratory results will be available through the participant patient portal.

There is no cost for you to participate in our research study.