This study is being done because many children with Down syndrome may have CVI, a brain‑based vision problem, but most are never diagnosed. Early diagnosis is important because CVI can affect how children see, learn, and do everyday activities. Researchers want to find out if a simple eye‑tracking test can help detect CVI more easily so children can get the right support sooner.

Your family may be eligible for this study if your child meets the following criteria.

Inclusion Criteria:

• Down syndrome

• Ages 4–12 years

• Speaks English or Spanish

Exclusion Criteria:

• Photosensitive epilepsy

• Certain eye conditions (such as congenital cataracts)

• Any condition identified during the eye exam that prevents accurate testing

The study includes 1 or 2 in‑person visits, depending on whether the child is diagnosed with CVI. All study activities take place over a short period of time, not months or years.

• Visit 1 (all participants):

  • Children will complete a full eye exam with a pediatric neuro‑ophthalmologist.

  • They will do visual perception tests, which are simple activities that help us understand how they use their vision.

  • They will take part in eye‑tracking, where they look at pictures on a computer screen while a special camera measures where their eyes move.

  • Parents will complete questionnaires about their child’s vision and daily activities.

  • These tests help the research team find out whether the child meets the criteria for CVI.

  Visit 2 (only for children diagnosed with CVI):

  • Children will complete a functional vision test with a teacher for the visually impaired.

  • This helps the team understand what challenges the child may have when using vision in everyday life.

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Participants may receive up to $50 in compensation for their time.  Children also receive a free eye exam from a pediatric neuro‑ophthalmologist.

Free parking, and rideshare support may be available for some participants.

There is no cost for your family to participate in our research study.