This study aims to understand whether DMT—a naturally occurring psychedelic compound found in the traditional Amazonian brew Ayahuasca—combined with psychotherapy, can reduce alcohol cravings. The study is designed to explore how psychedelic-assisted therapy may offer new hope for individuals seeking treatment for heavy drinking.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Heavy alcohol use
• No desire to stop or reduce alcohol consumption
• Able to undergo MRI scan (no metal in the body, no claustrophobia)
• Not diagnosed with major psychiatric disorders (e.g., schizophrenia, bipolar disorder)
• Ages 21-65
• In good general health
• Not pregnant or breastfeeding

What to expect if you participate in the study:

• In-Person Screening Visit

  • Meet with the research team

  • Review eligibility and medical history

  • Complete consent forms and initial assessments

• fMRI Brain Imaging Sessions

  • Undergo non-invasive brain scans

  • Help researchers understand brain activity related to alcohol use

• Test Day

  • Participate in a monitored alcohol session

  • Receive study medication (DMT or placebo)

  • Engage in brief psychotherapy

• One-Night Inpatient Stay

  • Stay overnight at the research facility for safety and observation

• Follow-Up Visits

  • Attend remote and in-person check-ins

  • Complete additional assessments and questionnaires

• Optional PET Scan Days

  • Participate in advanced brain imaging to measure specific brain chemistry

Participants will be compensated for their time and effort throughout the study with up to $1,850 plus transportation costs.

There is no cost for you to participate in our research study.

If you have any questions about this study, feel free to contact us at abn.lab@yale.edu.