This study is being conducted to examine how an FDA-approved sleep medication may interact with commonly used drugs, like opioids.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Currently use non-prescription opioids
• Willing to complete a 2-week stay at a residential research unit
• Ages 18-65

This study takes about 2-3 weeks and is completed in-person.

First, you will complete a brief phone screen (~15 minutes). If you seem eligible, you will complete an in-person screening visit (~3-4 hours). Then, if you are determined eligible by the clinical research team and would like to proceed, you will be enrolled for a 14-16 day stay on our residential research unit.

While you are in the residential unit, you will:

• Be maintained on a stable dose of hydromorphone to help reduce any potential withdrawal symptoms.
• Receive an FDA-approved sleep medication, called suvorexant, and have your sleep monitored.
• Complete five study sessions where you’ll complete surveys and tasks to assess your mood, well-being, craving, and cognition.

Participants may receive up to $2,780 in compensation for their time. In addition, while you are staying at the research unit, all meals and snacks will be provided.

There is no cost for you to participate in our research study.