The purpose of this research study is to examine the effects of treatment with clozapine vs antipsychotic treatment as usual for adults with schizophrenia.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 18-65
• Living with schizophrenia or schizoaffective disorder
• Recent minor or serious act of violence
• No severe or unstable medical or neurological conditions
• Able to commute to Manhattan, NY for study visits

Overall Duration

• Once enrolled, this 24-week study involves weekly study visits for 6 months (24 weeks).

What’s Involved

• Baseline assessment and medical screening
• Randomization into one of two study groups
• Receiving either clozapine or another antipsychotic medication
• 3 initial outpatient clinic visits (2-3 hours total)
• Completion of questionnaires and blood draws
• 24 weekly outpatient clinic visits
• This study is conducted in NYC at the 125th street clinic of Manhattan Psychiatric Center. We are close to major subways (2,3,4,5 and 6)

Compensation up to $950 will be provided to those who qualify for full study completion, which includes 3 initial outpatient clinic visits (2-3 hours total), completion of questionnaires and blood draws, and 24 weekly outpatient clinic visits. You will receive reimbursement for travel expenses.

There is no cost for you to participate in our research study.