Study Description

The purpose of this study is to determine if different types of exercise (stationary cycling versus walking on a treadmill) impact certain bone markers.

You may qualify for this study if you meet the following criteria.

Once enrolled, this study involves:

• Participants are required to come to the University of Colorado Anschutz Health and Science Building for 7-9 total study visits.

  • The first visit includes going over the consent form, meeting with the Nurse Practitioner of the study for a short physical exam, a fasted blood draw, and DEXA bone density scan.

  • The second visit involves a Graded Exercise Test (GXT) where the participant is required to walk on a treadmill for 10-15 minutes while we made the test more challenging by increasing the incline every 2 minutes. We also have the participant hooked up to an EKG monitor during this test to see how the heart response to exercise.

  • After “passing” these two visits we moved them onto the exercise familiarization visit where they bike for 20 minutes, rest for 15, and walk on a treadmill for 20. At that point they are ready for the exercise collection visits where they are randomized into either walking on a treadmill or biking for an hour.

  • If a participant is randomized to walking on the treadmill first, they will come in and walk on a treadmill for an hour at a heart rate that we determine from the GXT visit. This visit lasts approximately 7 hours, and we take blood draws before, during, and up to 4 hours after exercise.

  • They are also expected to come in for a 24-hour post exercise draw and an optional 48-hour draw.

  • A week later, they then come in for the other exercise they did not complete (for this example a stationary bike) where they will have the same set of blood draws before, during, and after exercise.

Participants will be compensated up to $200.

There is no cost for you to participate in this study.