Endometriosis Research Study
Researchers at the University of Pennsylvania School of Medicine are seeking premenopausal women experiencing pain due to endometriosis.
Fast Facts
Premenopausal Women Ages 18-50
Experience Moderate to Severe Pain due to Endometriosis
Compensation Provided
Conducted in Philadelphia, PA
Study Background
Do you experience pain from endometriosis? Are you willing to use non-hormonal birth control or are you not at risk for pregnancy?
This study is looking at the impact on bone health of an FDA approved medication to manage heavy menstrual bleeding associated with fibroids and moderate to severe pain due to endometriosis.
Your participation in the study would last for five years. You would take the medication for four years and have one year of follow-up. You would come to our Penn Medicine clinic in Philadelphia every 6 months, where we would ask you questions about your health and do the study-related blood tests. You would undergo a DXA bone density scan at these visits, which is a form of low dose X-ray.
Findings from this study will help us evaluate changes in bone mineral density during continuous treatment with the study medication in women experiencing moderate-to-severe pain associated with endometriosis.
Study Background
Do you experience pain from endometriosis? Are you willing to use non-hormonal birth control or are you not at risk for pregnancy?
This study is looking at the impact on bone health of an FDA approved medication to manage heavy menstrual bleeding associated with fibroids and moderate to severe pain due to endometriosis.
Your participation in the study would last for five years. You would take the medication for four years and have one year of follow-up. You would come to our Penn Medicine clinic in Philadelphia every 6 months, where we would ask you questions about your health and do the study-related blood tests. You would undergo a DXA bone density scan at these visits, which is a form of low dose X-ray.
Findings from this study will help us evaluate changes in bone mineral density during continuous treatment with the study medication in women experiencing moderate-to-severe pain associated with endometriosis.
Additional Information
The purpose of this research study is to evaluate the impact on bone health of a daily medication for pain relief for premenopausal women experiencing moderate to severe pain associated with endometriosis.
You may qualify for this study if you meet the following criteria.
Inclusion Criteria:
- Women ages 18-50
- Experience moderate to severe pain due to endometriosis
- Not at-risk for pregnancy or willing to use a reliable, non-hormonal method of birth control
- Have not gone through menopause
- Not currently pregnant or breastfeeding
- Have not used Depo-Provera (Depo) as a contraceptive method for more than 2 years in the past 5 years
- No history of deep vein thrombosis (DVT) or pulmonary embolism
- Have not experienced migraines with aura (visual disturbances like flashing lights or zigzag patterns) or other specific neurological symptoms
- Do not use tobacco products
- No BRCA mutation or a personal history of breast cancer
- No uncontrolled high blood pressure
- No liver disease or any liver impairment
- Not dependent on any substances, such as alcohol or non-prescribed drugs
- Have not been diagnosed with osteoporosis
- Do not experience uterine bleeding
Once enrolled, this study involves receiving the study drug for 48 months. Participants will attend in-person visits every six months and complete bone density scans, as well as scheduled phone calls between visits. Participants will also attend follow-up visits during the year after completing the treatment.
Compensation is provided up to $3250 for your participation.
There is no cost for you to participate in our research study.
