The purpose of this study…

You may qualify for a study if you meet the following criteria.

Inclusion Criteria:

• 15-25 years old
• Current depressive disorder
• Healthy individuals with no history of psychiatric disorders

Exclusion Criteria:

• Lifetime psychosis or bipolar disorder
• Serious, unstable neurological disorders, including seizures, epilepsy, stroke, or brain tumor (does not include headache or migraine)
• Brain injury with loss of consciousness
• Traumatic brain injury that required hospitalization
• MRI contraindications (claustrophobia, metal in body, weight over 300 lbs)

The entire study lasts 1-2 years. Once enrolled, the study involves:

• In the lab: 3-4 visits where you’ll complete assessments of characteristics of depression and dopamine systems. Each assessment includes an interview, questionnaires, a computer task, and an MRI scan. The interview will be video and audio recorded, and the first visit also includes a blood draw.
• From home: You’ll also do app-based “digital phenotyping,” in which we ask about your mood and experiences and collect information from your phone. With this, you would be asked to take a survey several times per day, nine days out of the month. The survey will take less than 5 minutes to complete, and the app will also track word contents but not the recipients of the messages.

As a participant, you can receive up to $2580, as well as transportation costs.