HIV & Depression Research Study

Researchers at Emory University are conducting a study on depression and inflammation in people living with HIV.

Fast Facts

Experiencing Depressive Symptoms

Diagnosed with HIV & on Continuous Antiretroviral Therapy for at Least 12 Months

Compensation

Provided

Conducted in

Atlanta, GA

Study Background

Understanding how inflammation affects depression in people with HIV.

People living with HIV are at increased risk for experiencing depression, and researchers are working to understand why. One possibility is that inflammation in the body and brain may play a role in causing or worsening symptoms of depression. The Behavioral Immunology Program at Emory University is conducting a research study to explore how anti-inflammatory medication may impact brain function and mood in individuals living with HIV.

This 12-week study involves brain imaging, lab work, and psychiatric assessments. Participants do not need to have a formal diagnosis of depression, but should be experiencing symptoms of low mood or other signs of depression. The goal is to learn more about how treating inflammation may help relieve depressive symptoms in people with HIV.

Study Background

Understanding how inflammation affects depression in people with HIV.

People living with HIV are at increased risk for experiencing depression, and researchers are working to understand why. One possibility is that inflammation in the body and brain may play a role in causing or worsening symptoms of depression. The Behavioral Immunology Program at Emory University is conducting a research study to explore how anti-inflammatory medication may impact brain function and mood in individuals living with HIV.

This 12-week study involves brain imaging, lab work, and psychiatric assessments. Participants do not need to have a formal diagnosis of depression, but should be experiencing symptoms of low mood or other signs of depression. The goal is to learn more about how treating inflammation may help relieve depressive symptoms in people with HIV.

Additional Information

Researchers want to better understand how inflammation may contribute to depression in people living with HIV, and whether anti-inflammatory medication can help improve symptoms.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

  • Diagnosed with HIV (that is well-controlled)
  • On continuous antiretroviral therapy (ART) for at least 12 months
  • Experiencing depressive symptoms (e.g., feeling sad, tired, hopeless, or not enjoying things you used to)
  • Ages 18-65
  • HIV is well-controlled (viral loads are low or undetectable)
  • No diagnosis of Hepatitis B or C
  • Able to have an MRI scan (e.g., pacemaker, claustrophobia, metal implants)
  • If female, not pregnant, actively trying to become pregnant, or breastfeeding
  • Complete a brief phone screening to check eligibility

  • Attend a study orientation visit at Emory

  • Participate in 6–8 study visits over 12 weeks

  • Each visit lasts approximately 3 to 6 hours

  • Visits include MRI brain scans, blood draws, psychiatric and cognitive assessments

  • Transportation (Uber) is provided as needed

  • Receive snacks and copies of your lab work

Yes, participants can receive up to $1300 for completing the study. Snacks are available during visits, and Uber rides can be arranged to and from appointments.

There is no cost for you to participate in our research study.