Healthy Volunteer Research Study
Researchers at The Fenway Institute are conducting a study on a combination of three antibodies against HIV to understand how the immune system responds when they are given together at different doses.
Fast Facts
Healthy Adult Volunteer
HIV Negative
Compensation
Provided
Conducted in
Boston, MA
Study Background
We are testing a combination of study antibodies to learn how the body responds and to see if they are safe.
HVTN 206/HPTN 114 is a research study in Greater Boston looking at how the immune system reacts when people receive three study antibodies against HIV together and at different doses. HIV is the virus that can cause AIDS if left untreated. The study antibodies are not made from actual HIV, and they cannot give you HIV. Antibodies are proteins your body naturally makes to help fight infection. Researchers want to understand how much of these study antibodies stay in the body over time, how the immune system responds, and if the combination is well-tolerated.
This is an in-person study with about nine clinic visits over 12 months. At two visits, participants will receive the study antibodies through an IV infusion (“a drip”). At each visit, researchers will collect blood samples to measure immune response and antibody levels. Participants will also complete questionnaires, have physical exams, and receive routine testing for HIV, sexually transmitted infections (STIs), and pregnancy (if applicable).
Study Background
We are testing a combination of study antibodies to learn how the body responds and to see if they are safe.
HVTN 206/HPTN 114 is a research study in Greater Boston looking at how the immune system reacts when people receive three study antibodies against HIV together and at different doses. HIV is the virus that can cause AIDS if left untreated. The study antibodies are not made from actual HIV, and they cannot give you HIV. Antibodies are proteins your body naturally makes to help fight infection. Researchers want to understand how much of these study antibodies stay in the body over time, how the immune system responds, and if the combination is well-tolerated.
This is an in-person study with about nine clinic visits over 12 months. At two visits, participants will receive the study antibodies through an IV infusion (“a drip”). At each visit, researchers will collect blood samples to measure immune response and antibody levels. Participants will also complete questionnaires, have physical exams, and receive routine testing for HIV, sexually transmitted infections (STIs), and pregnancy (if applicable).
Additional Information
We want to learn if giving three study antibodies together at different doses is safe, how the body’s immune system responds, and how long the antibodies stay in the body.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
- Healthy adult volunteer
- HIV negative
- Not currently pregnant or breastfeeding
- Have not received immunoglobins (e.g., IVIG, subcutaneous immunoglobulin, hepatitis B immune globulin) within last 60 days
- Have not received blood products (e.g., red blood cells, platelets, plasma) within last 60 days
- Ages 18-65
- Willing to use a medically accepted birth control method for the study’s duration if applicable
You will come to the clinic for about nine visits over 12 months. At two visits, you’ll receive the study antibodies through an IV infusion. At each visit, we will collect blood samples, conduct routine HIV/STI and pregnancy testing (if applicable), and ask you to complete questionnaires. You may also have brief phone call visits, and you will complete entries in an eDiary on your phone.
Eligible participants may receive compensation. Reasonable travel expenses, including ridesharing within 15 miles, parking, and public transportation, may be reimbursed with a receipt. Participants also receive free STI and pregnancy testing (if applicable).
There is no cost for you to participate in our research study.