Researchers at Rutgers University are exploring whether combining guanfacine—a medication that may reduce stress—and mindfulness therapy can help people on buprenorphine better manage opioid cravings. The goal is to find new ways to support long-term recovery and emotional well-being.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Adults 18-65 years old

• Have a diagnosis of opioid use disorder

• Currently taking buprenorphine

• Interested in quitting opioid use

• Willing to commit to phone and in-person visits at Rutgers, online surveys, a 6-week program with study medicine and mindfulness, and a follow-up call

Exclusion Criteria:

• Currently pregnant or breastfeeding

   

Here’s what to expect, step by step:

1. Phone Screening: A brief call to confirm eligibility.

2. Visit 1 (Rutgers): In-person physical exam, drug/pregnancy tests, and mental health assessments.

3. Visit 2 (Remote): Online assessments of memory, emotions, and trauma history.

4. Imagery Training (Remote): Learn relaxation and visualization techniques.

5. Lab Session 1 (Rutgers): Exposure to stress and opioid-related imagery while researchers monitor responses.

6. Treatment Phase (6 weeks): You’ll receive either Guanfacine or placebo, and attend weekly therapy sessions (either mindfulness-based or support group).

7. Lab Session 2 (Rutgers): Repeat imagery exposure with new visuals to measure changes.

8. Follow-Up (Remote): A final check-in one week after treatment ends.

Yes! Participants can earn up to $470 for completing all study visits and sessions. Compensation is provided after each step, and remote sessions are designed to be flexible. If you’re traveling to Rutgers for in-person visits, transportation support may be available—just ask the study team when you enroll.

There is no cost for you to participate in our research study.