Menstrual Cycle Research Study
Researchers at Oregon Health & Science University (OHSU) are conducting a study to better understand the causes of heavy menstrual bleeding related to the uterine lining, with the goal of improving future testing and treatment options.
Fast Facts
Have a regular menstrual cycle (21-35 days)
Not currently using hormonal medications
Compensation
provided up to $400
Conducted in
Portland, OR
Study Background
Heavy menstrual bleeding can significantly impact daily life, yet the biological reasons why it occurs are not fully understood.
Abnormal Uterine Bleeding caused by the endometrium (AUB-E) occurs when the lining of the uterus does not regulate bleeding as it should. While many people experience heavy periods, others do not—and the reasons for these differences remain unclear. This lack of understanding can make diagnosis and treatment challenging.
This research study uses advanced laboratory and imaging tools to closely examine the uterine lining across the menstrual cycle. By learning more about how normal bleeding is controlled and what changes in people with heavy periods, researchers hope to support the development of better diagnostic tests and expand treatment options for those affected by AUB-E.
Study Background
Heavy menstrual bleeding can significantly impact daily life, yet the biological reasons why it occurs are not fully understood.
Abnormal Uterine Bleeding caused by the endometrium (AUB-E) occurs when the lining of the uterus does not regulate bleeding as it should. While many people experience heavy periods, others do not—and the reasons for these differences remain unclear. This lack of understanding can make diagnosis and treatment challenging.
This research study uses advanced laboratory and imaging tools to closely examine the uterine lining across the menstrual cycle. By learning more about how normal bleeding is controlled and what changes in people with heavy periods, researchers hope to support the development of better diagnostic tests and expand treatment options for those affected by AUB-E.
Additional Information
This study aims to understand the biological causes of heavy menstrual bleeding related to the uterine lining and why it affects some people but not others.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
- Individuals ages 18-45
- Have a regular menstrual cycle (21-35 days)
- Not currently using hormonal medications, or willing to stop for study
- No known bleeding disorder diagnosis
- No known or suspected anatomical/structural abnormalities that could cause heavy menstrual bleeding (Uterine fibroids, polyps, adenomyosis, etc)
- No diagnosis of PCOS
- Willing to use study-provided disposable pads and tampons for one period
If you join the study, you may be asked to complete up to 2–3 in-person visits at OHSU’s Marquam Hill Campus, along with some at-home tracking:
Screening & Enrollment Visit (1–2 hours)
Review and sign the consent form
Answer questions about your medical history
Blood draw
Complete a bleeding questionnaire
Receive at-home ovulation test kits and instructions
Receive a menstrual bleeding tracking form (PBAC) and study-provided pads and tampons
Transvaginal (Pelvic) Ultrasound (if needed)
A low-risk imaging procedure to evaluate the uterus
Only required if you have not had one in the past 6 months
Endometrial Biopsy Visit (about 1 hour)
Scheduled 10–14 days after ovulation
Includes a pregnancy test, blood draw, and tissue sampling from the uterine lining
Optional medication may be offered to help you relax
You will also complete at-home ovulation testing and track menstrual bleeding for one cycle.
Participants can receive up to $400 for their time and effort:
- Screening Visit: $50
- Final Study Visit (Biopsy): $275
- PBAC Completion: $25
Additional perks include:
- Free bloodwork with results
- Free transvaginal ultrasound and provider consultation (if not done recently)
- Free parking
- Ride passes for the Portland Aerial Tram to and from study visits
There is no cost for you to participate in our research study.