In this research study, we are trying to better understand how schizophrenia spectrum disorders (SSD) change as people age. We aim to explore age-related differences in brain function and cognitive abilities, such as memory, attention, and thinking processes, in individuals living with SSD. Although there is growing recognition of the long-term impact of schizophrenia spectrum disorders, many questions remain about how these conditions evolve over time. By studying both individuals with SSD and healthy participants, we hope to identify important patterns in brain and cognitive aging that could help inform future care, improve long-term outcomes, and guide the development of more targeted interventions for people living with psychosis.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Between the ages of 35 and 65
• Diagnosis of a Schizophrenia Spectrum Disorder
• No neurological problems
• No past month history of drug/alcohol abuse
  
  

Exclusion Criteria:

• Past-month history of drug or alcohol abuse
• Poorly controlled medical conditions, including poorly controlled diabetes or clinically significant hypo- or hyperthyroidism (based on self-report)
• Body mass index (BMI) greater than 40
• Active inflammatory disease
• History of organ transplant or neoplasm within the past 6 months
• Recent myocardial infarction or unstable angina
• History of head trauma with loss of consciousness greater than 2 minutes
• Currently pregnant, breastfeeding, or within 2 months of delivery or miscarriage
• MRI contraindications (e.g., non-removable metal in or on the body, severe claustrophobia)

The entire study takes place over several study visits. Once enrolled, the study involves:

In the lab:
You will complete a telephone pre-screening followed by up to four in-person or remote study visits. These visits include a screening visit and three study visits. During these visits, you will complete interviews, questionnaires, computer-based cognitive assessments, and biological measures. Two of the visits will involve MRI brain scans conducted at the University of Alabama at Birmingham and Auburn University. A urine drug screen will be completed during one visit, and a blood sample will be collected during one of the MRI visits. Transportation will be provided for select visits.

From home:
Some study activities may be completed remotely, including the initial phone screening and portions of the screening visit, depending on eligibility and scheduling. Research staff will guide you through all steps of participation and provide support throughout the study.

As a participant, you may receive up to $310. 

There is no cost for you to participate in our research study.