PTSD Research Study
Researchers from Boston Medical Center/Boston University are looking for individuals to participate in a treatment development study for PTSD. The purpose of the study is to investigate effects of a natural, anxiety-reducing, stress hormone (allopregnanolone) on brain processes critical to PTSD recovery. Join our compensated study today.
Fast Facts
Possible Chronic Post Traumatic Stress Disorder
Generally healthy and not taking daily psychiatric medications
Willing to abstain from alcohol for 2 weeks and from nicotine, marijuana, or illicit drugs for 4 weeks before and throughout the study
Compensation Provided
Conducted in Greater Boston, Massachusetts
Study Background
Boston Medical Center/Boston University is looking for individuals ages 18 to 55 years old who are not on daily psychiatric medications to participate in a PTSD treatment development study. The purpose of the study is to investigate effects of a natural, anxiety-reducing, stress hormone (allopregnanolone) on brain processes critical to PTSD recovery.
Posttraumatic stress disorder (PTSD) is a major public health concern, affecting 6.4% of the general U.S. population (8.6% of women and 4.1% of men) with up to 20% rates among individuals exposed to high-risk trauma such as combat, compound community trauma, and sexual assault.
Your participation in this research study may help researchers improve treatment approaches for PTSD. Contribute to research today and join our compensated study!
Study Background
Boston Medical Center/Boston University and is looking for individuals ages 18 to 55 years old who are not on daily psychiatric medications to participate in a PTSD treatment development study. The purpose of the study is to investigate effects of a natural, anxiety-reducing, stress hormone (allopregnanolone) on brain processes critical to PTSD recovery.
Posttraumatic stress disorder (PTSD) is a major public health concern, affecting 6.4% of the general U.S. population (8.6% of women and 4.1% of men) with up to 20% rates among individuals exposed to high-risk trauma such as combat, compound community trauma, and sexual assault.
Your participation in this research study may help researchers improve treatment approaches for PTSD. Contribute to research today and join our compensated study!
Additional Information
Once enrolled, this study involves:
- 2 screening visits to determine psychological and medical eligibility:
- Consent Process (~½ – 1 hour): occurs before the first screening evaluation (either remote or in-person)
- Psychological Screening Evaluation (~3.5 hours): interviews & questionnaires about traumatic experiences, psychiatric & medical symptoms
- Medical Screening Evaluation (~2.5 hours): physical exam, EKG, color blindness, hearing & cognitive testing, & urine, saliva & blood collection for medical, drug, nicotine, alcohol & pregnancy tests
- For the Pharmacokinetics (PK) Studies, there are 2 in-person research visits scheduled 2 days in-a-row:
- Day 1 (~9 hours): Intravenous (IV) allopregnanolone infusion, questionnaires, blood draws & memory testing
- Day 2 (~3 hours): questionnaires, blood draw & memory testing
- For the Main Studies, there are 3 in-person research visits scheduled 3 days in-a-row plus a follow-up phone/Zoom call about 1-week later:
- Day 1 (~3.5 hours): questionnaires, blood draw, memory & startle testing
- Day 2 (~9 hours): Intravenous (IV) allopregnanolone or placebo infusion, questionnaires, blood draws, memory & startle testing
- Day 3: (~3.5 hours): questionnaires, blood draws, memory & startle testing
- 1-week Follow-up (~45 minutes): questionnaires
