Veteran PTSD
Research Study

Researchers at The University of Pennsylvania are partnering with military veterans who are currently experiencing symptoms of PTSD to determine the most effective treatment for symptoms. Join our compensated study today!

Fast Facts

18-75 Years Old

Military Veteran

Currently experiencing symptoms of PTSD

Compensation up to $275 Provided

Conducted at VA Medical Centers

Study Background

Researchers at The University of Pennsylvania are conducting a research study to determine the most effective treatment for military veterans with PTSD.

Findings from this study will provide information on whether psychotherapy (Prolonged Exposure Therapy), pharmacotherapy (medications such as Paxil and Effexor), or a combination of the two can reduce symptoms of PTSD in military veterans. This study will examine the impact these treatments have on PTSD symptoms, mood, and social life. Additionally, this data will help predict which treatment option will be best for an individual, based on their personal characteristics.

Participants will complete an in-person baseline assessment (3-4 hours), followed by a 7 week, 14 week, 27 week, and 40 week follow-up assessment. The follow-up assessments consist of surveys that will take 1-2 hours each, and may be completed virtually. Participants will also complete biweekly surveys (will take 10-20 minutes to complete) during active treatment, up to week 14. The total study duration is 40 weeks. The study will be conducted at active participating VA sites, including Philadelphia, Coatesville, Dallas, Milwaukee, and San Diego.

Further research today and join our compensated study!

Further research today and join our compensated study!

Additional Information

The purpose of this clinical research study is to determine whether undergoing Prolonged Exposure Therapy while taking medication is more helpful than either treatment alone in reducing symptoms of PTSD among military veterans.

You may qualify for this study if you meet the following criteria:

Key Criteria:

  • Between 18-75 years old
  • Military veteran
  • Currently experiencing symptoms of PTSD
  • Willing to participate in prolonged exposure therapy, pharmacotherapy, or both
  • No active psychosis or history of manic episodes. and no current suicidal ideation with intent/plan, or suicidal behaviors in the past month
  • Not currently pregnant
  • Have not previously tried these study medications (Paxil and Effexor) or Prolonged Exposure therapy but failed to benefit
  • No ongoing medical conditions or treatments that would have potential interactions with paroxetine and venlafaxine (such as MAO inhibitors)

Once enrolled, this study involves:

  • Completing a baseline assessment consisting of surveys, interviews, and in-person tasks (3-4 hours)
  • Attending a 7 week, 14 week, 27 week, and 40 week follow-up assessment that can be completed virtually (1-2 hours each)
  • Answering surveys every two weeks until the week 14 follow-up (10-20 minutes to complete each survey)

Compensation is provided up to $275 for your time.

There is no cost for you to participate, as treatments are covered by your VA benefits.