The increasing prevalence of alternative nicotine products has highlighted the need for research to assess their health effects and potential benefits in reducing traditional cigarette smoking. This voluntary study seeks to evaluate a new oral nicotine pouch, focusing on its impact on health and its effectiveness as a smoking cessation tool. By exploring these outcomes, researchers aim to provide evidence-based insights into the role of nicotine pouches in harm reduction strategies for tobacco users.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 21-70
• Smoke at least 5 cigarettes per day for the past 12 months
• Not interested in quitting smoking at this time
• Interested in trying an alternative nicotine product (Zyn nicotine pouches)
• Able to understand, read and write in English
• Have access to email and a smartphone or computer with a reliable internet connection
• Live in the Houston, TX area and are willing to travel for some in-person appointments

Exclusion Criteria:

• Currently pregnant, breastfeeding, or planning to become pregnant in the next 6 months

If you participate in this study, here is what you can expect:

1. Study Duration: The study will last about 21 weeks from start to finish.

2. Study Contacts: You will have a total of 9 contacts with the research team:

   • 2 virtual meetings.

   • 2 phone calls (15-30 minutes each).

   • 5 in-person visits, some lasting over an hour.

3. Questionnaires: At various points, you will answer questionnaires about your experience and health.

4. Biological Samples: During in-person visits, you will provide samples such as:

   • Exhaled carbon monoxide (breath test).

   • Urine and mouth cell samples.

5. Study Product: You will return any unused nicotine pouches provided by the study team and report any side effects you experience while using them.

6. Health Monitoring: Your vital signs, such as heart rate, blood pressure, height, and weight, will be measured during in-person visits.

This process ensures a thorough evaluation of the nicotine pouch and its effects on your health.

• Total Payment: If you complete the full study, you can earn up to $475.

• Payment Breakdown:

  • In-Person Visits with Sample Collection: $65 each (Visits 2, 6, and 8).

  • Other In-Person Visits: $50 each (Visits 5 and 7).

  • Virtual Study Contacts: $25 each.

  • Phone Calls: $15 each.

  • Completion Incentive: $100 at the end if you:

    • Finish all study contacts ($50).

    • Submit at least 90% of daily nicotine pouch and cigarette use logs ($50).

• Transportation Support: You’ll receive either parking validation (up to $12 per visit) or a Metro pass based on how you travel for the study visits.

• Partial Payment: If you decide not to finish the study, you will still be paid for the visits you complete.

There is no cost for you to participate in our research study.