Insomnia Treatment Study
Researchers at Stanford University are conducting an insomnia treatment study to better understand how improving sleep can reduce depressive symptoms and support emotional well-being.
Fast Facts

Experience insomnia that impacts your daily life and/or mood

18-65
Years Old

Compensation
provided for participation

Conducted in
Palo Alto, CA
Study Background
Stanford University researchers are conducting a compensated insomnia treatment study.
The SleepMORE Study at Stanford University examines how unhealthy sleep patterns contribute to emotional distress by disrupting brain networks involved in emotion regulation. Insomnia is closely linked with depressive symptoms, and difficulties with sleep can worsen mood, motivation, and overall daily functioning. This study aims to determine whether a proven insomnia treatment can improve sleep quality and reduce depressive symptoms by helping to normalize these brain networks.
By combining sleep assessments, clinical evaluations, and neuroimaging measures, the SleepMORE Study seeks to better understand the relationship between sleep, brain function, and emotional well-being. The findings from this research may help inform more effective, sleep-based treatments for insomnia and depression and ultimately improve quality of life for individuals experiencing sleep difficulties.
Study Background
Stanford University researchers are conducting a compensated insomnia treatment study.
The SleepMORE Study at Stanford University examines how unhealthy sleep patterns contribute to emotional distress by disrupting brain networks involved in emotion regulation. Insomnia is closely linked with depressive symptoms, and difficulties with sleep can worsen mood, motivation, and overall daily functioning. This study aims to determine whether a proven insomnia treatment can improve sleep quality and reduce depressive symptoms by helping to normalize these brain networks.
By combining sleep assessments, clinical evaluations, and neuroimaging measures, the SleepMORE Study seeks to better understand the relationship between sleep, brain function, and emotional well-being. The findings from this research may help inform more effective, sleep-based treatments for insomnia and depression and ultimately improve quality of life for individuals experiencing sleep difficulties.
Additional Information
In the SleepMORE Study at Stanford University, researchers are working to better understand how insomnia and unhealthy sleep patterns affect mood and emotional well-being. Poor sleep can disrupt brain networks involved in regulating emotions, which may contribute to depressive symptoms and daily distress. This study uses clinical assessments, sleep measurements, and neuroimaging to examine how these brain networks function in individuals experiencing insomnia and depression-related symptoms.
The goal of this research is to determine whether a proven insomnia treatment can improve sleep quality and reduce depressive symptoms by helping to normalize emotion regulation brain networks. By combining neuroscience-based methods with an evidence-based sleep intervention, the SleepMORE Study aims to inform more effective treatments for insomnia and mood symptoms and support improvements in overall quality of life.
You may be eligible to participate in this study if you meet the following criteria:
Inclusion Criteria:
- Ages 18–65
- Experience insomnia associated with daytime impairment or distress
- Report depressive symptoms
- Reside within 60 miles of Stanford University
Exclusion Criteria:
- History of psychotic or bipolar disorders
- Serious or unstable neurological conditions (e.g., seizures, epilepsy, stroke, brain tumor; does not include headaches or migraines)
- Brain injury involving loss of consciousness or traumatic brain injury requiring hospitalization
- MRI contraindications, including claustrophobia, metal in the body, or body weight exceeding scanner limits
The entire study lasts several months. Once enrolled, the study involves:
In the lab:
4 in-person two-part visits at Stanford University, which include overnight sleep recordings and MRI scans. During these visits, you will complete interviews and questionnaires related to sleep, mood, and emotional functioning.
From home:
You will participate in 3 Zoom study sessions and complete 6 therapy sessions, which may be conducted over Zoom or in person depending on your preference. These sessions will include sleep- and mood-related assessments to help researchers understand how insomnia treatment affects brain function and emotional well-being.
Participants may receive compensation for their time and effort for completing study visits, with transportation support available for certain in-person sessions.
There is no cost for you to participate in our research study.