HIV And Depression Research Study
Researchers at Florida International University are conducting the TRIDENT Study to understand how a depression-focused therapy may improve health outcomes for people living with HIV in South Florida.
Fast Facts
Living With HIV
Experiencing Depression, Low Mood, or Loss of Interest
in Things Normally Enjoyed
Compensation
Provided Up To $1,015
Conducted in
Miami, FL
Study Background
This research study is exploring how treating symptoms of depression may positively affect the gut microbiome, immune functioning, and brain health in people living with HIV.
The TRIDENT Study is a 10-month clinical research study led by Dr. Adam Carrico at Florida International University, with visits conducted primarily at the University of Miami Medical Campus. People living with HIV often experience symptoms of depression, which may influence physical health in ways not yet fully understood. This study aims to identify how a targeted cognitive-behavioral therapy program (CBT-AD) may improve both mood and biological markers of health.
By participating, individuals will take part in surveys, biospecimen collection, neuropsychological testing, and two fMRI scans, along with a 12-week course of CBT-AD. The findings from this study will help researchers better understand the pathways that drive depressive symptoms among people with HIV, potentially informing future care approaches for the community.
Study Background
This research study is exploring how treating symptoms of depression may positively affect the gut microbiome, immune functioning, and brain health in people living with HIV.
The TRIDENT Study is a 10-month clinical research study led by Dr. Adam Carrico at Florida International University, with visits conducted primarily at the University of Miami Medical Campus. People living with HIV often experience symptoms of depression, which may influence physical health in ways not yet fully understood. This study aims to identify how a targeted cognitive-behavioral therapy program (CBT-AD) may improve both mood and biological markers of health.
By participating, individuals will take part in surveys, biospecimen collection, neuropsychological testing, and two fMRI scans, along with a 12-week course of CBT-AD. The findings from this study will help researchers better understand the pathways that drive depressive symptoms among people with HIV, potentially informing future care approaches for the community.
Additional Information
This study aims to understand how treating symptoms of depression may influence the gut microbiome, immune system, and brain functioning in people living with HIV.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
- Living with HIV
- Experiencing depression, low mood, or a loss of interest in things you normally enjoy
- Able to undergo an MRI scan (no non-removable metal in your body or extreme claustrophobia)
- Ages 18+
Participants will complete a series of steps over approximately 10 months, including:
A phone screening interview
In-person visits at the University of Miami Medical Campus
Surveys and questionnaires
Biospecimen collection
Neuropsychological and cognitive testing (in-person)
Two fMRI scans
A 12-week cognitive-behavioral therapy program (CBT-AD)
*Some study visits may be completed virtually, depending on the visit type.
Participants can receive up to $1,015 for completing all study activities. A W-9 form is required for compensation. If transportation is a barrier, the study team may arrange Uber Health rides upon request, although this is not broadly advertised.
There is no cost for you to participate in our research study.