Fast Facts
Experiencing Symptoms of Depression with No History of Bipolar Disorder or Mania/Hypomania
Willing To Join A Depression Clinical Trial
Ages 18-60
Conducted in
Pittsburgh, PA
Study Background
At the University of Pittsburgh, researchers are exploring an innovative approach to treating depression, focusing on a new medication and a brain training program designed to reshape thought patterns and evaluate its potential for quick antidepressant results.
Depression is a challenging condition that affects millions, often leading to ongoing sadness, negative thinking, and withdrawal from everyday activities. These struggles can impact not just mental well-being but also overall health. Despite the treatments available, many individuals continue to face significant barriers to recovery, highlighting the need for more effective and faster-acting solutions.
This study aims to explore a new approach to treating depression. Researchers are testing an experimental medication that may provide rapid relief from depressive symptoms, alongside a computer-based training program designed to help the brain develop healthier thought patterns. Over a 45-day period, participants will undergo interviews, assessments, and this innovative treatment combination to better understand how these interventions can change the way the brain processes information and improve overall mental health.
Study Background
At the University of Pittsburgh, researchers are exploring an innovative approach to treating depression, focusing on a new medication and a brain training program designed to reshape thought patterns and evaluate its potential for quick antidepressant results.
Depression is a challenging condition that affects millions, often leading to ongoing sadness, negative thinking, and withdrawal from everyday activities. These struggles can impact not just mental well-being but also overall health. Despite the treatments available, many individuals continue to face significant barriers to recovery, highlighting the need for more effective and faster-acting solutions.
This study aims to explore a new approach to treating depression. Researchers are testing an experimental medication that may provide rapid relief from depressive symptoms, alongside a computer-based training program designed to help the brain develop healthier thought patterns. Over a 45-day period, participants will undergo interviews, assessments, and this innovative treatment combination to better understand how these interventions can change the way the brain processes information and improve overall mental health.
Additional Information
This study aims to explore a faster-acting medication and a computer-based brain training program to address persistent depression symptoms and improve mental health outcomes for individuals who struggle with current treatments.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
- Experiencing symptoms of depression
- Willing to join a depression clinical trial
- Ages 18-60
- Able to attend study visits in Pittsburgh, PA
Exclusion Criteria:
- History of bipolar disorder or mania/hypomania
- Serious or unstable medical conditions
- Ongoing/recent severe substance use dependency
- History of psychosis or autism spectrum disorders
- History of Huntington’s, Parkinson’s, Alzheimer’s, Multiple Sclerosis, strokes, or one or more seizures without a clear and resolved etiology
- Pregnant, breastfeeding, or planning to conceive a child in the next 6 months
- Currently taking opioid medications
- Have received electroconvulsive therapy (ECT) within the past 6 months
- Currently receiving VNS or rTMS treatments
- Participating in other clinical trial of an investigational product or device
If you decide to participate in this study, here’s what you can expect:
Virtual Consent and Screening: The process starts with a virtual session where you’ll learn about the study, provide consent, and complete an initial screening interview.
In-Person Visits: You’ll attend about 11 in-person appointments, which include:
A thorough medical and lab screening to ensure safety and eligibility.
Receiving an infusion of either the experimental drug (apimostinel) or a placebo.
Completing 4 days of practice with a computer-based brain training task designed to help improve thinking patterns.
Follow-Up Assessments:
In-person check-ins will occur periodically over the next 45 days to monitor progress.
After that, you’ll have monthly virtual follow-ups for 2-6 months to track longer-term effects.
Participants can earn up to $300 for full completion of the study.
There is no cost for you to participate in our research study.