In this research study, we are examining how depression develops in LGBTQ+ high school students. We are particularly interested in how social experiences, like relationships with peers and parents, relate to brain systems involved in reward, motivation, and positive emotions. We will measure these brain systems, along with participants’ experiences and behaviors, to better understand how they may contribute to depression during adolescence.

You may be eligible for this study if you meet the following criteria:

Inclusion Criteria:

• Ages 14–18 and currently in high school
• Self-identify as a sexual minority (LGBTQ+) or are questioning
• Mid-to-late stage of puberty

Exclusion Criteria:

• History of head injury, neurological disorder, pervasive developmental disorder, or serious medical illness
• Daily nicotine use
• MRI contraindications (non-removable metal, severe claustrophobia)
• Pregnancy
• Diagnosis of bipolar or psychotic disorder
• Recent alcohol/substance use disorder (except cannabis in last 3 months)

The study lasts about 6-7 months.

• In-person: Participants will come to the lab for 1 visit at the University of Pittsburgh. During this visit, you’ll complete assessments related to depression and emotional experiences, including questionnaires and an MRI scan.

• Virtual: Participants will complete 2 Zoom interviews over 6 months. The first interview will include a clinical interview where you will be asked about your mood and life experiences. At a later visit, done over Zoom, you’ll answer questionnaires on your electronic device.

As a participant, you may receive up to $180 for completing the study, and travel costs for attending the in-person visit at the University of Pittsburgh will be reimbursed.

There is no cost for you to participate in our research study.