In this research study, we are investigating how memory changes as people age and what factors support healthy cognitive aging. We aim to better understand the brain systems that underlie memory, attention, and learning in older adults. Memory performance is influenced by brain structure, neural activity, and physiological factors, all of which we will measure in this study. By examining these mechanisms, we hope to identify strategies that may help maintain memory and cognitive function over time. To do this, we use a multimodal approach including neuropsychological testing, physiological measurements, and MRI scans to study the brain and behavior comprehensively.

You may be eligible for this study if you meet the following criteria:

Inclusion Criteria:

• Ages 20–30 or 60–95
• Healthy, cognitively normal adults with no history of neurological or psychiatric disorders

Exclusion Criteria:

• Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
• Presence of another neurologic disorder, which could impact findings (e.g. multiple sclerosis)
• Cardiovascular disease, stroke, congestive heart failure
• Active hematological, renal, pulmonary, endocrine or hepatic disorders.
• A history of active alcohol or substance abuse 
• Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol
• MRI contraindications, such as the presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
• Body Mass Index exceeding 33 (BMI limit of the MRI table)
• Pregnancy
• Currently breastfeeding
• Unwilling to return for follow-up, undergo neuropsychological testing and MR imaging
• Left-handedness
• Site investigator’s discretion, if they feel the subject cannot complete sufficient key study procedures. Exceptions to these guidelines may be considered on a case-by-case basis at the discretion of the Project Director
• Active psychiatric disorder or use of psychiatric medication
• Medications that may affect peripheral physiology or vasculature

The entire study lasts 1–2 years. Once enrolled, participation involves three in-person or virtual visits:

In the lab / in-person:

• Session 1 (virtual, Zoom): Complete informed consent, questionnaires, and neuropsychological testing (up to 2.5 hours).
• Session 2 (in-person at MGH Charlestown Navy Yard): MRI scan while performing memory tasks and connected to physiological monitoring equipment (up to 4 hours, with no more than 2 hours in the scanner).
• Session 3 (in-person at Northeastern University): Computer-based memory and affective tasks while physiological data are collected (up to 3 hours).

As a participant, you may receive up to $250. 

There is no cost for you to participate in our research study.