In this research study, we are investigating how memory changes as people age and what factors support healthy cognitive aging. We aim to better understand the brain systems that underlie memory, attention, and learning in older adults. Memory performance is influenced by brain structure, neural activity, and physiological factors, all of which we will measure in this study. By examining these mechanisms, we hope to identify strategies that may help maintain memory and cognitive function over time. To do this, we use a multimodal approach including neuropsychological testing, physiological measurements, and MRI scans to study the brain and behavior comprehensively.

You may be eligible for this study if you meet the following criteria:

Inclusion Criteria:

• Ages 60–85
• Healthy, cognitively normal adults with no history of neurological or psychiatric disorders

Exclusion Criteria:

• Lifetime history of psychosis or bipolar disorder
• Serious or unstable neurological disorders (e.g., seizures, epilepsy, stroke, brain tumor; headaches or migraines are not excluded)
• History of brain injury resulting in loss of consciousness
• Traumatic brain injury requiring hospitalization
• MRI contraindications (e.g., claustrophobia, metal in the body, pacemakers, or weight exceeding MRI limits)

The entire study lasts 1–2 years. Once enrolled, participation involves three in-person or virtual visits:

In the lab / in-person:

• Session 1 (virtual, Zoom): Complete informed consent, questionnaires, and neuropsychological testing (up to 2.5 hours).
• Session 2 (in-person at MGH Charlestown Navy Yard): MRI scan while performing memory tasks and connected to physiological monitoring equipment (up to 4 hours, with no more than 2 hours in the scanner).
• Session 3 (in-person at Northeastern University): Computer-based memory and affective tasks while physiological data are collected (up to 3 hours).

As a participant, you may receive up to $250. 

There is no cost for you to participate in our research study.