This study is being conducted to evaluate whether a two-week morning light intervention may influence sleep, circadian rhythms, brain function, mood, and recovery-related outcomes in individuals receiving treatment for opioid use disorder. Researchers hope the findings will help improve understanding of how sleep and circadian health relate to recovery.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 18-60
• Currently receiving methadone or buprenorphine treatment for opioid use
• Able to attend in-person study visits at UAB in Birmingham
• Not pregnant or currently breastfeeding
• Have used opioids for at least 12 months in lifetime

• If you choose to participate, you will complete several study activities over approximately three weeks, including both at-home monitoring and in-person visits at UAB.

Initial Visit

• Review and sign the informed consent form
• Complete screening assessments and questionnaires
• Receive an eye exam
• Learn how to use study-provided monitoring devices

Baseline Monitoring Week

• Wear a sleep and activity watch

• Complete brief daily smartphone surveys

• Complete two nights of overnight sleep recordings from home

Lab Visit 1

• Complete an MRI scan

• Complete pupil response testing

• Provide saliva samples

• Complete questionnaires

Light Intervention Period (2 Weeks)

• Use a study-provided light device for 30 minutes each morning
• Continue wearing monitoring devices and completing daily surveys

Lab Visit 2

• Repeat assessments completed during Lab Visit 1 so researchers can evaluate changes following the intervention

Participants who complete the study may receive up to $869 for their time and participation.

Additional study benefits include:

• Free comprehensive eye exam
• Copy of your sleep report
• $15 meal allowance during both Lab Visit 1 and Lab Visit 2
• Parking costs will be reimbursed. 

There is no cost for you to participate in our research study.