Influenza Vaccine
Research Study
Researchers at National Institutes of Health are studying a new flu vaccine that may protect against different flu strains. Participants will complete a telephone screening visit followed by an in-person screening visit to determine eligibility. If eligible, participants will receive a new flu vaccine or placebo, and later take part in a supervised inpatient stay to help evaluate how well the vaccine works against an H1N1 flu virus. The study will take place at the NIH Clinical Center in Bethesda, MD. There is a minimum of 8 outpatient visits and a 9-calendar day inpatient stay. The study duration is 5-8 months.
Fast Facts
Healthy adults
aged 18-55
Non-smoker
& non-vaper
Compensation up to $3970 may be provided
Conducted in DC Metro area. If beyond DMV area, apply if willing to travel!
Additional Information
This study is looking at whether an investigational vaccine called BPL-1357 can help protect against H1N1 influenza. Researchers want to find out if it could work as the basis for a universal flu vaccine in the future.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
- Adults 18 to 55 years old
- Non-smokers/non-vapers (no tobacco or cannabis use)
- BMI between 18 and 35
Exclusion Criteria:
- Chronic cardiovascular or pulmonary disease (such as high blood pressure, asthma, or diabetes)
- History of an adverse reaction to a vaccine
- Allergy to two or more classes of antibiotics, or an allergy to influenza treatments
Adults outside of the DC/Maryland/Virginia (DMV) area are welcome to apply if willing to travel.
Overall Duration
- The study has two parts and takes several months total to complete.
Part 1: Vaccination
- You’ll receive either the investigational vaccine or a placebo, given as a shot and/or a nasal spray
- About a week later, you’ll have a short check-in visit
- About a month after that, you’ll come back for a booster dose, followed by another short check-in visit a week later
Part 2: Inpatient Stay
- Two to four months later, you’ll be admitted to a special unit for at least 9 days
- You’ll be given the influenza virus under medical supervision
- You’ll have daily physical exams, vital signs checks, and nasal swabs to monitor for the virus
- You’ll be discharged once your swabs show no virus for at least 2 days
- You’ll return for two follow-up visits after you leave, at one month and two months
Other Details
- Blood draws happen periodically throughout the study
- Meals are provided during the inpatient stay
Compensation up to $3970 may be provided (excluding travel, lodging, & meals).
There is no cost for you to participate in our research study.