Researchers believe that there is a growing need to develop new treatment options for OUD. This research study explores the short-term effects of cannabinoids among persons with OUD who are receiving treatment with methadone.

You may qualify to participate in this study if you meet the following criteria.

Inclusion Criteria:

• 18-70 years old
• Diagnosed with opioid use disorder (OUD)
• Currently taking buprenorphine (suboxone) or methadone as treatment for opioid use
• Have used cannabis at least once in the past, but currently don’t use it on a daily basis
• Able to attend the research center in New Haven for 4 in-person visits

Exclusion Criteria:

• Bipolar disorder or schizophrenia
• Significant neurological conditions (Alzheimer’s, dementia, stroke)
• Currently pregnant or breastfeeding
• Suicidal ideation
• Sickle cell disease or liver cirrhosis

This is not a treatment study. Although participants may experience temporary effects of the study medication, this is not to be expected to have long-term effects, as they will only receive a single dose on each test day.

Participation will last about 6-8 hours per day for 3-4 test visits.

During the test visits, participants will be asked to take medication containing a different dose each day. The study team can further elaborate on this.

Participants will be asked to complete questionnaires and computer testing.

Participants can be compensated up to $930 for participating. An additional $20 will be compensated for any additional study visits requested.

There is no cost for you to participate in our research study.