Gut, Kidneys, and Enteric Hyperoxaluria Research Study
Researchers at New York University are conducting a research study into the effects of enteric hyperoxaluria in people who are eating a pre-prepared diet.
Fast Facts
Kidney Stones in the Last 3 Years
Short Bowel Syndrome, Enteric Hyperoxaluria, or have undergone Small Bowel Resection or Roux-en-Y Gastric Bypass
Compensation Provided
Conducted in NYC
Study Background
Researchers at NYU Langone Health are studying the effects of enteric hyperoxaluria (EH) when you are given a pre-prepared diet.
EH is a condition in which a person’s body does not properly absorb fat in the gut, which leads to higher than normal levels of oxalate in your urine, a natural substance found in the human body and in many foods. People who have EH should follow a special diet to avoid foods that contain oxalate and fat, and they must take supplements (for example, calcium salts) to help the body get rid of extra oxalate.
If you have been diagnosed with kidney stones in the past 3 years AND have either short bowel syndrome, enteric hyperoxaluria, or have undergone small bowel resection or Roux-en-Y gastric bypass, you may be eligible to participate in this research study. The study will last about 28 days and will involve about 4 visits. While in this study, you will be asked to do the following:
- eat a prescribed diet for 8 days
- eat ¼ cup of spinach for 2 weeks
- gather stool collection
- partake in blood and urine tests
Study Background
Researchers at NYU Langone Health are studying the effects of enteric hyperoxaluria (EH) when you are given a pre-prepared diet.
EH is a condition in which a person’s body does not properly absorb fat in the gut, which leads to higher than normal levels of oxalate in your urine, a natural substance found in the human body and in many foods. People who have EH should follow a special diet to avoid foods that contain oxalate and fat, and they must take supplements (for example, calcium salts) to help the body get rid of extra oxalate.
If you have been diagnosed with kidney stones in the past 3 years AND have either short bowel syndrome, enteric hyperoxaluria, or have undergone small bowel resection or Roux-en-Y gastric bypass, you may be eligible to participate in this research study. The study will last about 28 days and will involve about 4 visits. While in this study, you will be asked to do the following:
- eat a prescribed diet for 8 days
- eat ¼ cup of spinach for 2 weeks
- gather stool collection
- partake in blood and urine tests
Additional Information
This research study is being done to look at how your gut bacteria breaks down a substance called oxalate and affects your oxalate level in the urine and your risk of developing kidney stones.
You may qualify for a study if you meet the following criteria.
Inclusion Criteria:
- 18-80 years old
- Diagnosed with kidney stones in the last 3 years
- Diagnosed with either short bowel syndrome, enteric hyperoxaluria, OR have undergone small bowel resection or Roux-en-Y gastric bypass
Participants will be asked to be in the study for 27 days total and to visit NYU Langone Health (NYULH) 4 times.
The initial screening visit, Day 0, involves questions to make sure the participant is eligible for the study and a collection of relevant medical history. A physical exam will be performed and study materials will be dispensed. If eligible, participants will then proceed to:
Days 1-4
- eat a prepared diet
- stool collection
- 24 hour urine collection
Day 5
- return to NYU to drop off collections
- partake in a blood collection
Days 9-22
- consume 1/4 cup of spinach daily (optional)
- stool collection on Day 14
Days 23-26
- repeat study procedures as completed on Days 1-4
Day 27
- complete a blood collection
- drop off collections
You will be compensated for your time and participation in this study.
There is no cost for you to participate in our research study.
