The goal of this study is to better understand how sleep quality may influence cognition and brain function in adults ages 65-85 who have sleep troubles.

You may qualify if you meet the following criteria.

Inclusion Criteria:

• Ages 65-85 years old
  
• Difficulties staying asleep at night
• Able to undergo an MRI

• Currently taking psychiatric medications
• Diagnosed with bipolar disorder, schizophrenia, any other psychotic disorder
• Currently diagnosed with depression or panic disorder
• History of electroconvulsive therapy
• Drug or alcohol dependence within the past 6 months (Note: Drug testing is not involved in our study)
• History of stroke, brain cancer, seizure disorder, epilepsy, a severe head or brain injury, fractured skull, or loss of consciousness greater than 24 hours
• Diagnosed with Multiple Sclerosis, Parkinson’s, Huntington’s, Alzheimer’s disease, or any other neurodegenerative disease

This study will last approximately 2 months, and will consist of 4 in-person visits and several at-home activities. The in-person visits are as follows:

• Screening Visit
• PET Scan Visit, which includes a 20-30 min PET scan and a neuropsychological assessment
• Overnight Visit 1, which includes cognitive tasks, questionnaires, polysomnography, blood draw, and an MRI brain scan. Breakfast will also be included.
• Overnight Visit 2, which includes cognitive tasks, questionnaires, polysomnography, blood draw, and an MRI brain scan. Breakfast will also be included.

At home activities will involve:

• Wearing an ActiGraph watch (similar to a pedometer)
• One-night sleep apnea screening
• Sleep diary
• Following a specific sleep schedule  for a 4-week period.

As a participant, you can receive up to $599 for completing all study activities. Transportation can also be provided.

There is no cost for you to participate in our research study.