Fast Facts
Ages 18+
Diagnosed with thyroid cancer
Transportation Provided
Conducted Nationally
Study Background
Help us learn more about treatment options for thyroid cancer.
This study aims to help patients with a type of thyroid cancer that does not respond to standard treatments, specifically those whose cancer has spread and does not absorb radioactive iodine. By using a specialized imaging technique called 68Ga-DOTATATE PET/CT, researchers will look for high levels of a specific receptor, known as somatostatin receptor type 2 (SSTR2), in the tumors of these patients. This one-time imaging procedure is designed to identify those who might benefit from different treatment strategies.
The main goal of the study is to compare how common it is to find high SSTR2 expression in patients with this challenging form of thyroid cancer. By understanding the prevalence of this receptor in tumors, researchers hope to gain insights that could lead to more effective treatment options for patients who currently have limited choices. This study could ultimately improve care for individuals facing this difficult diagnosis.
Study Background
Help us learn more about treatment options for thyroid cancer.
This study aims to help patients with a type of thyroid cancer that does not respond to standard treatments, specifically those whose cancer has spread and does not absorb radioactive iodine. By using a specialized imaging technique called 68Ga-DOTATATE PET/CT, researchers will look for high levels of a specific receptor, known as somatostatin receptor type 2 (SSTR2), in the tumors of these patients. This one-time imaging procedure is designed to identify those who might benefit from different treatment strategies.
The main goal of the study is to compare how common it is to find high SSTR2 expression in patients with this challenging form of thyroid cancer. By understanding the prevalence of this receptor in tumors, researchers hope to gain insights that could lead to more effective treatment options for patients who currently have limited choices. This study could ultimately improve care for individuals facing this difficult diagnosis.
Additional Information
You may qualify for a study if you meet the following criteria.
Inclusion Criteria:
- 18+ years of age
- Diagnosed with thyroid cancer
- Cancer has spread outside the thyroid
- Able to provide consent
There are two different categories of involvement for this study- Study 19-DK-0050, and Study 000079-DK. Details and involvement are outlined below:
Study 19-DK-0050 (Metastatic Thyroid Cancer Study):
- Objective: This study is for patients with thyroid cancer that has spread outside the thyroid. It aims to evaluate iodine uptake in cancer cells using a new imaging technique (124I PET/CT), comparing two preparation methods for radioactive iodine (RAI) treatment:
- Injection of recombinant human thyroid-stimulating hormone (TSH).
- Stopping thyroid hormone medication for four weeks to stimulate natural TSH.
- What will happen if you participate:
- You will have two admissions to the NIH Clinical Center, each lasting just over a week.
- You will return for annual follow-up visits over the next five years.
- All study-related tests, procedures, and medications are provided at no cost, and travel and lodging may be covered.
- Objective: This study is for patients with thyroid cancer that has spread outside the thyroid. It aims to evaluate iodine uptake in cancer cells using a new imaging technique (124I PET/CT), comparing two preparation methods for radioactive iodine (RAI) treatment:
Study 000079-DK (Thyroid Cancer Research Study with New Imaging Technique):
- Objective: This study is investigating a new imaging technique (68Gallium DOTATATE PET/CT) for thyroid cancer that has spread outside the thyroid. This technique has been shown to be safe and effective in patients with other types of tumors.
- What will happen if you participate:
- You will undergo a medical interview, a physical exam, and CT scans of the neck, chest, abdomen, and pelvis.
- The study will last for approximately three months.
- All tests and procedures are free, and travel and lodging may be provided.
Although monetary payment is not offered for this study, NIH will pay for Domestic flights and accommodations. The scan will be done for free in our facility.
There is no cost for you to participate in our research study.
