The purpose of this research study is to investigate whether the smoking medication varenicline and financial incentives can help individuals in their journey to quit using e-cigarettes.

You may qualify for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 18-40
• Use e-cigarettes daily or near daily and are interested in quitting
• Used cannabis in the past 30 days
• Do not smoke cigarettes regularly
• No serious or unstable medical/psychiatric disorder (including severe substance use disorders other than cannabis or tobacco use disorders) in the past 3 months
• Not currently pregnant, breastfeeding, or refusing to use an appropriate form of birth control
• No current use of medications for smoking cessation
• Willing to take varenicline for the standard 12-week course of treatment
• Able to attend study visits at one of the following sites: Charleston, Lancaster, or Pickens, SC

This study will last approximately 6 months and will include 17 in-person study visits. For 12 weeks of the study, you will receive medication and counseling.

While varenicline is not FDA-approved for e-cigarette cessation, it is FDA-approved for cigarette cessation.

As a participant, you can receive up to $1,050 for completing all study tasks.

There is no cost for you to participate in our research study.