Fast Facts
Ages 18-75
Diagnosed with Bipolar I Disorder
Compensation Provided
Conducted in Baltimore, MD
Study Background
Bipolar disorder affects people of all ages, and symptoms can be difficult for patients to navigate. Our team is recruiting people diagnosed with bipolar disorder who will complete questionnaires, a blood draw, and an MRI scan to help us understand changes over time in the brain and overall health of people receiving bipolar disorder treatment. This study includes a remote baseline visit and visits once a year for 4 years on the JHU campus in Baltimore, MD.
Study Background
Help us create a database of information to help researchers explore how genetics and other biomarkers are impacted by bipolar disorder and its treatment.
Bipolar disorder affects people of all ages, and symptoms can be difficult for patients to navigate. Our team is recruiting people diagnosed with bipolar disorder who will complete questionnaires, a blood draw, and an MRI scan to help us understand changes over time in the brain and overall health of people receiving bipolar disorder treatment. This study includes a remote baseline visit and visits once a year for 4 years on the JHU campus in Baltimore, MD.
The study involves five visits to Johns Hopkins over 13 to 15 weeks. Participants will take trazodone and a placebo during two 4-week periods, separated by a 4-week washout. Both participants and investigators will be blinded to the treatment order. Evaluations include health and memory assessments, three MRI brain scans, blood tests, and cognitive tests. Participants will also wear an actigraph to track movement and complete four home sleep studies. These measures aim to uncover how trazodone affects sleep quality and cognitive function.
Additional Information
You may qualify for a study if you meet the following criteria.
Inclusion Criteria:
- Ages 18-75
- Diagnosed with bipolar disorder
- Able to complete an MRI scan
- Willing to attend 1 visit a year in-person in Baltimore, MD
If you participate in this study, here is what you can expect:
- Online Baseline Visit: A Zoom interview about moods and behaviors
- Baseline In-Person Visit: You will complete questionnaires, a blood draw, an MRI, and tests of your memory and thinking (also known as neurocognition)
- 1 Time Each Year for 4 Additional Years: Repeat the questionnaires, blood draw, MRI, and neurocognition tests in person.
Participants will receive $375 for completing both components of the baseline visit (remote and in-person), and $250 for the in-person visit each year after that for a total of $1,375.
There is no cost for you to participate in our research study.
