Fast Facts
Use Fentanyl
Able to be Inpatient for Approximately 24-36 Hours
Compensation Provided
Philadelphia, PA
Study Background
Subjects will be randomized to one of two arms: standard initiation or a novel low-dose initiation approach. During standard initiation, subjects will start buprenorphine after at least 8 hours of abstinence, once they develop moderate opioid withdrawal. The novel low-dose initiation approach we are investigating begins with very low doses of buprenorphine before opioid withdrawal starts, and the dosages are escalated over 10 hours.
Study Background
Subjects will be randomized to one of two arms: standard initiation, in which subjects will start buprenorphine after at least 8 hours of abstinence, once they develop moderate opioid withdrawal; or a novel low-dose initiation approach, which is started without objective withdrawal and where buprenorphine doses are escalated over 10 hours, without ongoing use of full-agonist opioids. The safety, efficacy, and whether participants have retention with treatment at two weeks are also being tested.
Additional Information
You may qualify for this study if you meet the following criteria.
Inclusion Criteria:
- Ages 18+
- Use fentanyl
- Able to be inpatient for approximately 24 – 36 hours
- Able to take oral medication and be willing to adhere to the dosage regimen
Exclusion Criteria:
- No current benzodiazepine use
- No documented sensitivity to buprenorphine or naloxone
- Not currently pregnant or breastfeeding
Participants will be compensated $50 for completion of all in-person screening procedures and will be paid $125 for each inpatient day. Total possible compensation is $300.
There is no cost for you to participate in our research study. Travel compensation is provided as is Lyft for the inpatient visit.