Alcohol Use Research Study
Researchers at Yale University’s ABN Lab are conducting a study on psychedelic-assisted therapy combined with brief counseling to reduce alcohol cravings and support recovery.
Fast Facts
Adults Who Drink Heavily
Ages 21-65
Compensation Provided
Conducted in New Haven, CT
Study Background
Understanding How DMT, a Psychedelic Used in Traditional Medicine, Might Aid Recovery
This clinical research study investigates whether a single dose of DMT—a psychedelic compound found in Ayahuasca, combined with short-term psychotherapy can help reduce alcohol cravings and support recovery. The study includes advanced brain imaging, health assessments, and a monitored alcohol session to better understand how DMT affects the brain and behavior.
Participants will complete several visits over two years, including fMRI scans, a one-night inpatient stay, and optional PET imaging. The study is designed to explore how psychedelic-assisted therapy may offer new hope for individuals seeking treatment for heavy drinking. All procedures are overseen by trained medical professionals at Yale.
Study Background
Understanding How DMT, a Psychedelic Used in Traditional Medicine, Might Aid Recovery
This clinical research study investigates whether a single dose of DMT—a psychedelic compound found in Ayahuasca, combined with short-term psychotherapy can help reduce alcohol cravings and support recovery. The study includes advanced brain imaging, health assessments, and a monitored alcohol session to better understand how DMT affects the brain and behavior.
Participants will complete several visits over two years, including fMRI scans, a one-night inpatient stay, and optional PET imaging. The study is designed to explore how psychedelic-assisted therapy may offer new hope for individuals seeking treatment for heavy drinking. All procedures are overseen by trained medical professionals at Yale.
Additional Information
This study aims to understand whether DMT—a naturally occurring psychedelic compound found in the traditional Amazonian brew Ayahuasca—combined with psychotherapy, can reduce alcohol cravings and improve outcomes for individuals seeking treatment for Alcohol Use Disorder.
You may qualify for this study if you meet the following criteria:
Inclusion Criteria
- Adults aged 21–65
- Male and Female
- Heavy drinker
- Currently not seeking treatment for alcohol use
- Able to undergo MRI and other imaging procedures
Exclusion Criteria
- Have a history of psychotic disorders or bipolar disorder
- Are currently using other substances (excluding nicotine or caffeine)
- Have medical conditions that prevent safe participation (e.g., heart issues, seizure disorders)
- Are pregnant or breastfeeding
- Have contraindications for MRI or PET scans (e.g., metal implants, claustrophobia)
- Are currently taking medications that interfere with study procedures
What to expect if you participate in the study:
In-Person Screening Visit
Meet with the research team
Review eligibility and medical history
Complete consent forms and initial assessments
fMRI Brain Imaging Sessions
Undergo non-invasive brain scans
Help researchers understand brain activity related to alcohol use
Test Day
Participate in a monitored alcohol session
Receive study medication (DMT or placebo)
Engage in brief psychotherapy
One-Night Inpatient Stay
Stay overnight at the research facility for safety and observation
Follow-Up Visits
Attend remote and in-person check-ins
Complete additional assessments and questionnaires
Optional PET Scan Days
Participate in advanced brain imaging to measure specific brain chemistry
Participants will be compensated for their time and effort throughout the study with up to $1,850 plus transportation costs.
There is no cost for you to participate in our research study.