PTSD Research Study
Researchers at the University of Rochester are conducting a study to better understand how the brain responds to threat and reward in individuals with suspected or confirmed PTSD, with the goal of improving early detection and future treatments.
Fast Facts
Adults Who Have Experienced a Traumatic Event
Have Not Used Mental Health Medications in Last 6 Weeks and Do Not Have ADHD
Compensation Provided If Eligible
Conducted in Rochester, NY
Study Background
Understanding How the Brain Responds to Safe vs. Threatening Places
Researchers at the University of Rochester Neuroscience Department are conducting a study to explore how the brain processes threatening and rewarding experiences in individuals with suspected or confirmed PTSD. This research focuses on how the brain learns to associate specific places with danger (threat learning) or safety and positive outcomes (reward learning). By using functional MRI (fMRI) scans, the study aims to identify the brain activity patterns linked to these learning processes. The goal is to deepen our understanding of how people with PTSD may perceive and respond to their environment differently due to past traumatic experiences.
Ultimately, the study seeks to uncover brain-based and behavioral markers that could help detect PTSD earlier and guide the development of new, more effective treatments—including innovative approaches like virtual reality therapy. Although this is not a treatment study, participants will receive a free clinical evaluation, a picture of their brain, and up to $150 in compensation. By participating, individuals will not only gain insight into their own mental health but also contribute to critical research aimed at improving care for those affected by trauma and related mental health conditions.
Study Background
Understanding How the Brain Responds to Safe vs. Threatening Places
Researchers at the University of Rochester Neuroscience Department are conducting a study to explore how the brain processes threatening and rewarding experiences in individuals with suspected or confirmed PTSD. This research focuses on how the brain learns to associate specific places with danger (threat learning) or safety and positive outcomes (reward learning). By using functional MRI (fMRI) scans, the study aims to identify the brain activity patterns linked to these learning processes. The goal is to deepen our understanding of how people with PTSD may perceive and respond to their environment differently due to past traumatic experiences.
Ultimately, the study seeks to uncover brain-based and behavioral markers that could help detect PTSD earlier and guide the development of new, more effective treatments—including innovative approaches like virtual reality therapy. Although this is not a treatment study, participants will receive a free clinical evaluation, a picture of their brain, and up to $150 in compensation. By participating, individuals will not only gain insight into their own mental health but also contribute to critical research aimed at improving care for those affected by trauma and related mental health conditions.
Additional Information
This study is being conducted to explore how people who have experienced trauma process signals of safety and danger in their brains. By examining these patterns, researchers hope to uncover clues that could help identify PTSD earlier and guide the development of new, more effective ways to support those living with its effects.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
- Adults ages 18-60
- Experienced a traumatic event (e.g., physical assault, sexual violation, serious accident, combat, natural disasters)
- Have not used mental health medications (e.g., antidepressants) within the past 6 weeks
- Able to undergo an MRI (no non-removable metal in your body, no severe claustrophobia)
- Suspected or confirmed diagnosis of PTSD
- Do not have ADHD
- Right-handed
If you choose to participate, here’s what to expect:
Phone Interview (about 1 hour):
You’ll start with a phone call where a researcher will ask general questions about your medical, psychiatric, and trauma history to see if you may be eligible.In-Person Screening Visit (about 3 hours):
If you’re eligible based on the phone interview, you’ll be invited for a more in-depth psychological evaluation at the research site. This helps determine if you qualify for the next phase of the study.fMRI Study Visit (about 4 hours, on a different day):
If you’re eligible, you’ll return for a study visit where you’ll complete questionnaires, take part in eye-tracking tasks, and play a video game while your brain activity is recorded in an fMRI scanner.Comfort and Safety:
Some questions may feel sensitive or uncomfortable, but you’re always free to skip any you don’t want to answer. Other than this, there are no expected risks or benefits from participating.
Participants will not be paid for participating in the phone or in-person intake screening. However, if deemed eligible, you may receive compensation for completing the MRI study. Additionally, you will receive a free clinical evaluation and a picture of your brain.
There is no cost for you to participate in our research study.