Schizophrenia Research Study
Researchers at New York State Psychiatric Institute are conducting a study on clozapine for the prevention of violence in people with schizophrenia.
Fast Facts
Diagnosed With Schizophrenia or Schizoaffective Disorder
Compensation
Provided Up To $950
Conducted in
New York, NY
Study Background
This study aims to better understand whether clozapine can reduce violent behavior more effectively than other commonly used antipsychotic medications.
Violence can be a serious and challenging symptom for some individuals living with schizophrenia or schizoaffective disorder. While many antipsychotic medications help manage symptoms, research suggests that clozapine may be especially effective in reducing aggressive or violent behavior. However, more clinical evidence is needed to compare clozapine directly with other treatment options in a structured and controlled way.
In this study, participants will be randomly assigned to receive either clozapine or treatment as usual, meaning another antipsychotic medication. By comparing outcomes between these two groups, researchers hope to learn whether clozapine leads to a greater reduction in violence and can help guide future treatment decisions for individuals who may benefit most from this medication.
Study Background
This study aims to better understand whether clozapine can reduce violent behavior more effectively than other commonly used antipsychotic medications.
Violence can be a serious and challenging symptom for some individuals living with schizophrenia or schizoaffective disorder. While many antipsychotic medications help manage symptoms, research suggests that clozapine may be especially effective in reducing aggressive or violent behavior. However, more clinical evidence is needed to compare clozapine directly with other treatment options in a structured and controlled way.
In this study, participants will be randomly assigned to receive either clozapine or treatment as usual, meaning another antipsychotic medication. By comparing outcomes between these two groups, researchers hope to learn whether clozapine leads to a greater reduction in violence and can help guide future treatment decisions for individuals who may benefit most from this medication.
Additional Information
This study is being done to determine whether clozapine reduces violent behavior more effectively than other antipsychotic medications in people with schizophrenia or schizoaffective disorder.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
- Diagnosed with schizophrenia or schizoaffective disorder
- Had an incident involving violence in the last 6 months
- Able to take antipsychotic medication (either clozapine or other antipsychotic medication)
- If eligible, you will attend a screening visit where you may receive a diagnosis as part of the research process.
After screening, you will be randomly assigned to one of two groups:
Clozapine treatment
Treatment as usual with another antipsychotic medication
You will have weekly visits for up to 6 months.
If you are in the clozapine group, you will have a blood draw every week.
Every 4-8 weeks, you will complete questionnaires about symptoms and experiences.
All visits will take place within a short radius of the New York State Psychiatric Institute.
If you are eligible and participate, you will receive compensation for your time.
You will receive $50 to $100 for visits that include questionnaires.
You will receive $20 for the shorter weekly visits.
The total possible compensation is up to $950.
Local transportation costs are reimbursed to help you attend your visits.
There is no cost for you to participate in our research study.