Menstrual Cycle Research Study
Researchers at Oregon Health & Science University are conducting a study on abnormal uterine bleeding to better understand its biological causes and improve diagnosis and treatment options.
Fast Facts
Have regular menstrual cycles (21-35 days)
Experience heavy bleeding
Compensation
provided up to $400
Conducted in
Portland, OR
Study Background
This study aims to uncover why some individuals experience abnormal uterine bleeding while others do not.
Abnormal Uterine Bleeding due to endometrial causes (AUB-E) is a common condition that can significantly affect quality of life, yet its underlying biological mechanisms are not fully understood. The endometrium, the lining of the uterus, plays a key role in menstrual bleeding, but researchers are still working to understand what causes irregular or excessive bleeding in some individuals.
In this study, researchers will use advanced profiling tools to examine how the endometrium functions across the menstrual cycle. By collecting information such as blood samples, ultrasound imaging, and endometrial tissue, the study aims to identify patterns and markers that could lead to improved diagnosis, prevention strategies, and more effective treatments for those affected by AUB-E.
Study Background
This study aims to uncover why some individuals experience abnormal uterine bleeding while others do not.
Abnormal Uterine Bleeding due to endometrial causes (AUB-E) is a common condition that can significantly affect quality of life, yet its underlying biological mechanisms are not fully understood. The endometrium, the lining of the uterus, plays a key role in menstrual bleeding, but researchers are still working to understand what causes irregular or excessive bleeding in some individuals.
In this study, researchers will use advanced profiling tools to examine how the endometrium functions across the menstrual cycle. By collecting information such as blood samples, ultrasound imaging, and endometrial tissue, the study aims to identify patterns and markers that could lead to improved diagnosis, prevention strategies, and more effective treatments for those affected by AUB-E.
Additional Information
This study is being conducted to better understand the biological causes of abnormal uterine bleeding and to develop improved ways to diagnose, prevent, and treat this condition.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
- Individuals ages 18-45
- Have regular menstrual cycles (21-35 days)
- Experience heavy bleeding
- Not currently using hormonal medications
- No known bleeding disorder diagnosis
- Do not take medication to reduce heavy menstrual bleeding (ex. Tranexamic acid, Lysteada, or Amicar)
- No known or suspected anatomical/structural abnormalities that could cause heavy menstrual bleeding (Uterine fibroids, polyps, adenomyosis, etc.)
- No diagnosis of PCOS
- Willing to use study-provided disposable pads and tampons for one period
Participation lasts approximately 8–16 weeks (2–4 menstrual cycles) and includes 2–3 in-person visits:
Visit 1:
Review and sign consent forms, discuss your medical history, complete questionnaires about bleeding experiences, provide a small blood sample, and receive an ovulation kit and a menstrual tracking form (PBAC). A pelvic ultrasound will also be performed.At Home:
Use the ovulation kit to track your cycle and complete the PBAC form during your next period.Final Visit (Day 24–28 of your cycle):
Provide a small blood sample and undergo an endometrial biopsy (a brief procedure that may cause short-term discomfort).
You may receive up to $400 for completing all parts of the study:
$50 for the first visit
$25 for completing the menstrual tracking form (PBAC)
$50 for the ultrasound
$275 for the final visit
All study-related procedures, including any additional ultrasound if needed, are covered by the study.
There is no cost for you to participate in our research study.