Opioid Use Disorder Research Study
Researchers at the University of Utah and University of California San Diego are conducting a study on ketamine-assisted mindfulness therapy for adults with opioid use disorder who are currently taking buprenorphine.
Study Background
This study explores a new, whole-person approach to support long-term recovery from opioid use disorder by combining ketamine-assisted therapy with either mindfulness-based practices or supportive therapy.
Many individuals taking medications like buprenorphine are able to reduce opioid use, but still struggle with cravings, stress, and relapse. These challenges often stem from deeper patterns in how the brain processes reward, stress, and emotional pain. Traditional treatments may not fully address these underlying factors, leaving people vulnerable to returning to opioid use.
The KetaMORE study is designed to target these deeper challenges by combining ketamine-assisted therapy with mindfulness-based practices. Ketamine may help “reset” certain brain patterns and increase openness to change, while mindfulness training helps individuals build practical skills to manage cravings, cope with stress, and respond to difficult emotions. Together, these approaches aim to support not just reduced opioid use, but improved well-being, emotional balance, and long-term recovery.
Study Background
This study explores a new, whole-person approach to support long-term recovery from opioid use disorder by combining ketamine-assisted therapy with either mindfulness-based practices or supportive therapy.
Many individuals taking medications like buprenorphine are able to reduce opioid use, but still struggle with cravings, stress, and relapse. These challenges often stem from deeper patterns in how the brain processes reward, stress, and emotional pain. Traditional treatments may not fully address these underlying factors, leaving people vulnerable to returning to opioid use.
The KetaMORE study is designed to target these deeper challenges by combining ketamine-assisted therapy with mindfulness-based practices. Ketamine may help “reset” certain brain patterns and increase openness to change, while mindfulness training helps individuals build practical skills to manage cravings, cope with stress, and respond to difficult emotions. Together, these approaches aim to support not just reduced opioid use, but improved well-being, emotional balance, and long-term recovery.
Fast Facts
Diagnosed With Opioid Use Disorder
Currently Taking Buprenorphine
Compensation
Provided Up To $600
Conducted in
Salt Lake CIty, UT
Additional Information
This study is being conducted to develop more effective treatments for opioid use disorder by addressing both the biological and emotional factors that contribute to cravings and relapse.
You may be eligible for this study if you meet the following criteria.
Inclusion Criteria:
- Diagnosed with opioid use disorder
- Currently taking buprenorphine
- Have a support person who can escort you home after the ketamine session
- Not currently pregnant/breastfeeding
- Ages 18+
- Complete an initial screening and medical evaluation
- Participate in regular virtual therapy sessions (mindfulness-based or supportive group)
- Attend in-person ketamine dosing sessions in a monitored clinical setting
- Complete follow-up visits and brief check-ins to track mood, cravings, and substance use over time
Participants may receive up to $600 for completing study activities.
There is no cost for you to participate in our research study.