This study that is funded by National Institute of Health (NIH) is being conducted to better understand why diabetes develops in people with spinal cord injury and how newer medications such as semaglutide help them.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Diagnosed with type 2 diabetes
• Diagnosed with a spinal cord injury
• Ages 18-70
• Not underweight
• Live in Texas
• Not taking medications for weight loss (e.g., Wegovy, Ozempic)

First, you will be evaluated to determine if you are eligible for the study. If eligible, you will receive either semaglutide or a placebo for 6 months. During the study, your blood sugar, body weight, and overall health will be monitored. Before and after the treatment period on two separate in-person visits, you will complete detailed health evaluations, including tests of blood sugar control, body composition, liver health, heart function, continuous glucose monitoring, energy use, and stool sample collection. You will also have two in-person follow up visits that include a review of your medical history and a fasting blood draw. In addition, study staff will contact you every two weeks to monitor your health and any changes in your medical condition.

Yes, participants will be informed about their diabetes status and will receive compensation up to $2100.

There is no cost for you to participate in our research study.