Many people with OUD still experience cravings and relapse despite medication. This study aims to test whether combining ketamine therapy with mindfulness skills can better address the underlying stress, emotions, and habits that contribute to ongoing opioid use.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Diagnosed with opioid use disorder
• Currently taking buprenorphine
• Currently using opioids or other drugs that are not prescribed to you or using differently than prescribed
• Have a support person who can escort you home after ketamine session
• Not currently pregnant/breastfeeding
• Ages 18+

• Complete an initial assessment and medical evaluation
• Participate in regular virtual therapy sessions (mindfulness-based or supportive group)
• Attend in-person ketamine dosing sessions in a monitored clinical setting
• Receive support from trained staff during and after each session
• Complete follow-up check-ins to track mood, cravings, and substance use over time
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Participants can receive up to $600 for completing study activities.

There is no cost for you to participate in our research study.