This study is being done to better understand how sleep and brain activity are connected to memory changes. Researchers hope to find simple and non-invasive ways to detect early signs of brain aging.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Age 65-90

• Generally healthy

• Memory concerns

• Overall Duration
  This study lasts up to about 4 months and includes one virtual visit and up to 5 in-person visits.

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  In-Lab Activities

  Participants will visit the Stanford campus up to 5 times.

  • Virtual visit
    You will complete a 45 minute online session to learn about the study and give consent.
  • Visit 1: Sleep study (overnight)
    You will stay overnight at a sleep center. A soft cap with small sensors will be placed on your head to measure brain activity while you sleep. This is safe and non-invasive. You may also wear a watch that tracks your movement during sleep.
  • Visit 2: Memory and thinking tests
    You will complete simple tasks that test memory, language, and thinking skills. You will also have an MRI scan, which takes pictures of your brain using a strong magnet.
  • Visits 3 and 4: Brain imaging scans
    You will complete two PET scans on separate days. These scans look at certain proteins in the brain that are linked to aging and memory changes. A small amount of tracer is used for imaging.
  • Visit 5: Daytime brain activity recording
    You will wear a cap with sensors again while completing short computer tasks. This helps measure brain activity while you are awake.

  During study visits, researchers may collect data such as brain activity recordings, scan images, and responses from memory tests. No video or audio recording is used unless you are told ahead of time.

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Optional Notes / Additional Details

A study partner may be asked to help if you need assistance during the overnight visit.

Yes. Participants can receive about $450 for completing the study. You may also receive travel reimbursement for Uber or mileage up to $150. Free parking is available at the study site. Snacks may be provided during visits.

There is no cost for you to participate in our research study.