Researchers are studying whether metformin may help improve asthma symptoms and asthma control in adults who are overweight or obese. The findings from this study may help identify new treatment options for people living with asthma.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Diagnosed with asthma
• Overweight or obese

Exclusion Criteria:

• Have diabetes
• Taking GLP-1 medications for weight loss

• Other chronic lung disease, inclusive of chronic obstructive pulmonary disease, bronchiectasis, interstitial lung disease, pulmonary fibrosis

• Current smoker

• Currently pregnant or breastfeeding

If you choose to participate, you will first complete a phone screening interview to see if you may qualify for the study.

If eligible, participation will last about 7 months and includes:

• Four in-person visits
• Four telephone visits
• Four video visits

During the study, participants will:

• Answer questionnaires about their health and asthma symptoms
• Provide blood and urine samples
• Complete lung function testing
• Receive either metformin or a placebo as part of the study

You may qualify if you:

• Are 18 years of age or older
• Have physician-diagnosed asthma that is not well-controlled
• Are overweight or obese

You may not qualify if you:

• • Have diabetes or currently take metformin
  • Are taking GLP-1 medications for weight loss
  • Are pregnant, breastfeeding, or planning to become pregnant
  • Have certain heart or lung conditions
  • Smoke or have a significant smoking history

Participants may receive up to $535 for completing study activities.

The study is open to eligible participants located within 50 miles of Baltimore, Maryland. Study staff can discuss visit scheduling and additional study details during the screening process.

There is no cost for you to participate in our research study.