The purpose of this clinical research study is to evaluate, treat, and observe patients with Lyme disease over the long term. We want to learn more about how Lyme disease appears in different people so that we have specific benchmarks to refer to during future research.

You may qualify for this study if you meet the following criteria.

Key Criteria:

Ages 2-65

Have recently been diagnosed with Lyme disease

Must have medical provider for non-protocol-related care

Willing to travel to the NIH Clinical Center in Bethesda, MD

Once enrolled, this study involves:

• Undergoing a history and physical examination
• Completing a laboratory and diagnostic evaluation
• Routine blood and urine studies
• X-rays or other tests as clinically indicated
• Tests of other body fluids or tissues as clinically indicated
• If clinically indicated, standard treatment may be offered
• Attending follow-up visits at the end of therapy, 3, 6, and 12 months after
• Attending long-term follow-up visits every 6-12 months for up to 10 years
  • More or less frequent follow-up visits may be indicated as clinically appropriate
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Participants will be compensated for research procedures only. Clinical care will not receive compensation; however, there is no charge for clinical care.

Transportation assistance, per NIAID policy, will be offered to individuals who live more than 50 miles from the NIH campus in Bethesda, Maryland.

There is no cost for you to participate in our research study.