This study is evaluating whether an experimental PET imaging tracer called [11C]PS13 can detect different levels of brain inflammation in people with Alzheimer’s disease, mild cognitive impairment, and cognitively healthy adults. Researchers will compare these results with additional brain imaging that measures amyloid—and, in some participants, tau—to better understand changes associated with Alzheimer’s disease.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 55+
• Generally healthy with no memory concerns
• Can complete an MRI (no unremovable metal in body)
• Able to travel to Stony Brook University for study visits

Participation lasts several weeks and includes a total of 3–4 study visits. If you qualify, you will:

1. Complete an interview about your memory and thinking, cognitive screening tests, and a blood draw.
2. Undergo two brain PET scans using small amounts of radioactive imaging tracers ([11C]PS13 and [18F]florbetaben) administered through an IV.
3. Have blood collected during one PET scan through an arterial catheter placed before the scan.
4. Complete one brain MRI scan.

Participants will receive $360 for completing the study.

Transportation assistance is available. Uber or Lyft rides are provided to and from your home if you live within a 10-mile radius of Stony Brook University, and visitor parking will be validated for those who drive.

There is no cost for you to participate in our research study.