This study is evaluating whether an investigational PET imaging tracer called [11C]PS13 can detect differences in brain inflammation in people with mild cognitive impairment or Alzheimer’s disease. Researchers will compare these results with other brain imaging scans that measure amyloid and, for some participants, tau proteins to better understand changes associated with Alzheimer’s disease.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 55+
• Have mild cognitive impairment or Alzheimer’s disease
• Can complete an MRI (no unremovable metal in body)
• Able to travel to Stony Brook University for study visits

If you qualify and choose to participate, your involvement will last several weeks and include 3–5 study visits, depending on scheduling. Study procedures include:

1. A screening visit with questions about your memory and thinking, cognitive testing, and a blood draw.
2. A brain MRI scan.
3. Two to three PET brain scans using small amounts of investigational or approved imaging tracers administered through an IV.
4. During one PET scan, blood samples will be collected through an arterial catheter placed before the scan.
5. Researchers will review your study results. In some cases, MRI or PET scans may identify findings that could have potential health importance, and appropriate follow-up will be discussed.

Participants may receive 460 for completing the study.

Transportation assistance is also available. Uber or Lyft rides can be provided to and from home for participants living within a 10-mile radius of Stony Brook University, and parking validation is available for visitor parking.

As an additional benefit, the study’s brain imaging may identify findings with potential health significance that can be shared with you if appropriate.

There is no cost for you to participate in our research study.