This study, led by researchers at NYU Langone Health, is examining how iron levels in the brain and blood are related to cognitive ability and  brain structure in people with schizophrenia or schizoaffective disorder.

Our aim is to test whether iron deficiency contributes to poorer cognitive function and more severe symptoms. If this hypothesis is confirmed, treating the iron deficiency may lead to reduced symptoms and better cognitive function.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Ages 16-35
• Current diagnosis of schizophrenia or schizoaffective disorder
• Diagnosed with schizophrenia at age 14 or older

Exclusion Criteria:

• Serious brain or neurological disorder (e.g., epilepsy, seizures, multiple sclerosis, stroke)
• Intellectual disability or significant medical illness
• Unable to undergo an MRI (e.g., metal implants, pacemakers, pregnancy, claustrophobia)
• Loss of consciousness for more than 30 minutes
• Alcohol or drug dependence in the last 6 months

Overall Duration

• This study involves two in-person visits at NYU Langone Health in New York, NY.

What’s Involved

• Visit 1 (about 2.5 hours): consent process and a review of your medical history
• Visit 2 (about 4-5 hours): a brain MRI scan (about 1 hour), cognitive testing (about 1.5 hours), and a blood draw

You may be paid up to $250 for participating.

You will also receive:

• A report of your brain MRI
• Blood work results related to blood iron level and anemia
• Snacks and coffee provided during visits

No, you will not have to pay for any costs associated with being in this study. The costs associated with the study procedures will be covered by funds available to researchers conducting the study.