This study is being done to determine whether clozapine reduces violent behavior more effectively than other antipsychotic medications in people with schizophrenia or schizoaffective disorder.

You may be eligible for this study if you meet the following criteria.

Inclusion Criteria:

• Diagnosed with schizophrenia or schizoaffective disorder
• Willing to attend study visits at Augusta University
• Ages 18-65
• Had an incident involving violence in the last 6 months
• Able to take antipsychotic medication (either clozapine or other antipsychotic medication)

This study is conducted in-person. If eligible, you will first attend a screening visit where we will conduct assessments to determine if you will be eligible for the treatment portion of the study.

Study Visits

• You will be randomly assigned to receive either clozapine or treatment as usual (another antipsychotic medication)
• Weekly visits for up to 6 months
• Weekly blood draws for participants assigned to the clozapine group
• Questionnaires about your symptoms and experiences throughout the study

Participants may receive up to $950 for completing this research study. Lyft transportation is available to help you get to study visits.

There is no cost for you to participate in our research study.