Help Us Learn More About E. coli

Researchers at the Johns Hopkins Center for Immunization Research are partnering with healthy adults to investigate the effects of E. coli. Join our compensated study today!

Fast Facts

Healthy Adults 18-50 Years Old

Available for a 10 day inpatient study stay

no history of bowel disease

maximum Compensation $3860

Study Background

Researchers at Johns Hopkins Center for Immunization Research (CIR) are conducting a research study to evaluate the effects of E. Coli on healthy volunteers.

Diarrhea is the second-leading cause of death among children younger than 5 years old worldwide. Enterotoxigenic Escherichia coli (ETEC), a bacteria that causes diarrhea, can cause malnutrition and even death in children in low- and middle-income countries. ETEC also causes illness in travelers when they visit new places. The infection occurs when a person consumes food or liquid contaminated with the bacteria. Most people with ETEC will develop symptoms such as fever, abdominal pain, and diarrhea. A vaccine against ETEC could have a significant impact on children in low- and middle-income countries and the millions of people who travel to these countries each year.

This inpatient challenge study is being conducted at Johns Hopkins CIR. It is part of a larger research project to find a vaccine that will help keep children and travelers safe from ETEC bacteria.


Additional Information

The purpose of this inpatient challenge study is to learn more about ETEC infection in healthy people and to use this information to develop a vaccine for ETEC. Participants will be given the bacteria under controlled conditions and about 70% will likely develop diarrhea. Study staff will be on site 24 hours a day during the inpatient stay to watch for symptoms and provide care for study participants.

You may be eligible for this study if you meet the following criteria:

Key Criteria:

  • Healthy adult, 18-50 years old
  • Available for a 10 day inpatient study stay
  • No history of bowel disorders
  • HIV, Hepatitis B and C negative

This study involves:

  • Participating in 1-3 screening visits
  • Completing a 10 day inpatient stay
  • Completing one in-person follow-up visit and one phone call follow-up visit

Maximum compensation for completing all study requirements is $3860.

There is no cost for you to participate.